TITLE:
The Correlation between Mothers with Low Birth Weight History and Body Mass Index Leptin Levels, and Preeclampsia
AUTHORS:
Aryani Aziz, Johanes C. Mose, Anita Deborah
KEYWORDS:
Body Mass Index, Mother, Early Onset Preeclampsia, Late Onset Preeclampsia, Leptin Levels, Low Birth Weight
JOURNAL NAME:
Open Access Library Journal,
Vol.2 No.12,
December
21,
2015
ABSTRACT:
Preeclampsia (PE) is
one of the complications of pregnancythat significantly increases maternal and
fetal mortality and morbidity. Mothers who were born as low birth weight (LBW)
babies have risks for PE that are 2 - 3 times higher than maternal birth weight
≥ 2500 g. LBW history of the mother is also correlates with the incidence of
metabolic syndrome later in life including incresed of body mass index (BMI), hyperlipidemia, hypertension, stroke type 2
diabetes and cardiovascular accident (CVA). This study aimed at
assessing the correlation between the incidence of LBW history of the mother
with PE, BMI and leptin levels. This study was a retrospective study of maternal
LBW history with case control design as well as cross-sectional design to search
the correlation between BMI and leptin levels with the incidence of PE. This
study was conducted from December 2014 through February 2015 in Hasan Sadikin
Hospital Bandung. Data were analyzed using Spear-man Rank and Chi-Square, and
the significant difference was determined as α p =
0.017) and diastolic (r = ﹣0.498; p = 0.004) blood
pressure but did not correlated with the incidence of PE (r = 0.333; p = 0.127). The incidence of maternal
history of LBW was higher in cases of PE (p =
0.033). There was a correlation between LBW history and early onset
preeclampsia (EOPE) and late onset preeclampsia (LOPE) (r = 0.500; p = 0.048). There was no correlation between
LBW history of BMI (r = ﹣0.040; p = 0.830) and levels of
leptin (r = ﹣0.157; p = 0.390). There was a correlation of
BMI and leptin levels (r = 0.664; p =
0.0001) Maternal LBW history was correlated with increased incidence of
systolic and diastolic blood pressure and the incidence of EOPE and LOPE.