TITLE:
Dynamic Thiol-Disulphide Homeostasis in Patients with Multiple Sclerosis
AUTHORS:
Gonul Vural, Sadiye Gumusyayla, Hesna Bektas, Orhan Deniz, Merve Ergin, Ozcan Erel
KEYWORDS:
Multiple Sclerosis, Relapse, Oxidative Stress, Thiol-Disulphide Homeostasis
JOURNAL NAME:
World Journal of Neuroscience,
Vol.6 No.3,
July
20,
2016
ABSTRACT: Objective: The aim of this
study was to evaluate thiol-disulphide homeostasis in patients with Multiple
Sclerosis (MS) during attack and remission. Design and Methods: A total of 82
patients admitted to our clinic were divided into 2 groups according to whether
they are having an attack or not. Peripheral blood samples were taken from all
patients and their native thiol, disulphide and total thiol concentrations were
measured by a newly developed automated method. In addition, their
disulphide/native thiol, disulphide/total thiol and native thiol/total thiol
ratios were calculated. Results: The average disulphide values,
disulphide/native thiol and disulphide/total thiol ratios of the patients with
MS who were having an attack were found to be significantly higher compared to
those in remission (p = 0.001, p = 0.001, p = 0.001, respectively). Conclusion:
Our results have shown that thiol-disulphide balance was shifted to the
oxidative area during the relapse. These homeostasis parameters, which can be
easily measured by this newly developed method at low costs, may be important
in terms of showing the disease activity and presenting the underlying mechanisms
of the disease.