TITLE:
Helicobacter Pylori Infection Is Associated with Dyslipidemia and Increased Levels of Oxidized LDL in Type-2 Diabetes Mellitus
AUTHORS:
Mohamed Hasan Mukhtar, Wesam Ahmed Nasif, Abdullatif Taha Babakr
KEYWORDS:
H. pylori, Diabetes, Oxidized LDL
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.6 No.3,
July
12,
2016
ABSTRACT: Emerging data now indicate and address the strong
relationship between H. pylori infection and the incidence of Type 2 DM, a growing body of evidence suggests
that the infection with H. pylori may
be associated with insulin resistance, chronic inflammation, long-term diabetes
complications, and cardiovascular risk factors. The present study was conducted
to evaluate the relationship between the infection with Helicobacter pylori and
disturbance in Lipid profile in Type 2 Diabetic patients. One hundred and five
participants were enrolled, categorized into two groups of H. pylori positive cases and negative controls according to their
results of H. pylori IgG antibodies.
Subjects in both groups fill the structured questionnaire. Blood samples were
drawn for measuring the FBS, 2hr-PP blood sugar, HbA1c, Lipid profile and
oxidized LDL. The obtained results were statistically analyzed. The study
methodology was approved by the Biomedical Ethics Committee in the Faculty of
Medicine, Umm Al-Qura University, Makkah, KSA. 48 cases (45.7%) were diagnosed
as H. pylori seropositive and 57
(54.3%) were negative. There is no significant difference in the mean age or
mean BMI between the H. pylori negative and positive cases. Glycemic control was similar in the two groups.
Total Cholesterol was higher in cases of positive H. pylori compared to negative controls (P H. pylori positive compared to negative
controls (P Infection
with H. pylori is associated with
increased levels of Total Cholesterol, Triglycerides, LDL-C and oxidized LDL in
Type 2 Diabetic patients.