TITLE:
Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Juana Koslay, San Luis Province, Argentina
AUTHORS:
Susana Siewert, Federico Márquez, Gisela Mendoza, Gustavo Fernández, Irma González, Marta S. Ojeda
KEYWORDS:
Haplotypes, Alleles, Homozygotes, TCF7L2, Polymorphisms, Type 2 Diabetes Mellitus
JOURNAL NAME:
Open Access Library Journal,
Vol.2 No.3,
March
18,
2015
ABSTRACT:
Polymorphisms in the gene coding for transcription factor 7 like 2 (TCF7L2)
are recognized as the strongest common genetic risk factors for Type 2 Diabetes
Mellitus (T2DM) across multiple ethnicities. This study was conducted to evaluate
an association between TCF7L2 variants and diabetes susceptibility in the population
of Juana Koslay, San Luis, Argentina. We genotyped 2 single nucleotide polymorphisms
(SNP) rs7903146 and rs12255372 in controls and diabetic subjects. Association with
T2DM was found for both SNPs rs7903146 and rs12255372 in the whole sample (under
a dominant genetic model, the odds ratios (OR) were 3.43, 95% CI [1.879 - 6.255],
p i.e. CT or TG)
were more frequent in the group of T2DM. The impact of TCF7L2 variation on T2DM
risk in Juana Koslay population is compatible with that demonstrated by a range
of studies conducted in various ethnic groups.