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has been cited by the following article:

• TITLE: Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Juana Koslay, San Luis Province, Argentina

  AUTHORS: Susana Siewert, Federico Márquez, Gisela Mendoza, Gustavo Fernández, Irma González, Marta S. Ojeda

  KEYWORDS: Haplotypes, Alleles, Homozygotes, TCF7L2, Polymorphisms, Type 2 Diabetes Mellitus

  JOURNAL NAME: Open Access Library Journal, Vol.2 No.3, March 18, 2015

  ABSTRACT: Polymorphisms in the gene coding for transcription factor 7 like 2 (TCF7L2) are recognized as the strongest common genetic risk factors for Type 2 Diabetes Mellitus (T2DM) across multiple ethnicities. This study was conducted to evaluate an association between TCF7L2 variants and diabetes susceptibility in the population of Juana Koslay, San Luis, Argentina. We genotyped 2 single nucleotide polymorphisms (SNP) rs7903146 and rs12255372 in controls and diabetic subjects. Association with T2DM was found for both SNPs rs7903146 and rs12255372 in the whole sample (under a dominant genetic model, the odds ratios (OR) were 3.43, 95% CI [1.879 - 6.255], p i.e. CT or TG) were more frequent in the group of T2DM. The impact of TCF7L2 variation on T2DM risk in Juana Koslay population is compatible with that demonstrated by a range of studies conducted in various ethnic groups.