TITLE:
A Biomechanical Model of Human Lung Deformation Utilizing Patient-Specific Elastic Property
AUTHORS:
Behnaz Seyfi, Anand P. Santhanam, Olusegun J. Ilegbusi
KEYWORDS:
Biomechanical Model, Lung Deformation, Image Registration
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.7 No.6,
June
20,
2016
ABSTRACT: A biomechanical model is developed and validated for breathing-induced
deformation of human lung. Specifically, a subject-specific poro-elastic lung
model is used to predict the displacement over the breathing cycle and compared
with displacement derived from high resolution image registration. The lung
geometry is derived from four-dimensional computed tomography (4DCT) scan
dataset of two human subjects. The heterogeneous Young’s modulus is estimated
using inverse analysis method. The numerical simulation uses fluid-structure
interaction technique to solve the coupled airflow equations and structural
dynamics of the lung tissue. The modelled displacement is validated by
comparison with the 4DCT registration results.