TITLE:
Surveillance of Gonococcal Infections with Assessment of Their Antibiotic Susceptibility Pattern
AUTHORS:
Rajdev Sangita, Shah Arpita, Patel Aarohi, Mulla Summaiya
KEYWORDS:
Neisseria gonorrhoeae, Drug Resistance
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.6 No.2,
June
8,
2016
ABSTRACT: Context: Gonococcal infections are prevalent throughout the world
and remain a serious public health problem, with an estimated 106.1 million new
infections per year. Over recent years, the gonococcus has rapidly acquired
resistance to commonly used antibiotics and very few treatment options remain;
hence, regular monitoring of antimicrobial resistance is very important.Methods and Material: The
study was conducted from January 2012 to March 2013 after approved by IRB & HREC in
patients attending O&G and Skin & VD with the complaints of vaginal
discharge, cervical discharge, urethral discharge, dyspareunia, burning
micturition, lower abdominal pain & infertility. Endocervical swabsand urethral swabswere collected and cultured on
chocolate agar andmodified Thayer martin mediumidentification of organism was done by biochemical tests and
antimicrobial susceptibility testing was done by Kirby-Bauer disk diffusion method as per CLSI
guidelines. Results: FiveNeisseriawere
isolated in male (2.3%) patientsof reproductive age group (20-30years) with one found reactive
for HIV. All patients had history of heterosexual contact of 10-12 days before onset of urethral
discharge and burning micturition. All isolates were resistant to Penicillin,
Tetracycline and Ciprofloxacin. Only one isolate was resistance to
Azithromycin. Conclusions:There is a development of
resistance in gonococcal isolates to third generationcephalosporin and azithromycin and these are the drugs that
are given for syndromic management of casesas per NACO guidelines. So surveillance for antimicrobial
resistance is crucial for monitoring the emergence and spread of antibiotic
resistance in gonococcal isolates.