TITLE:
A Light-Deprivation Mouse Model Potentially for Studying the Complete Congenital Stationary Night Blindness
AUTHORS:
Chanyi Lu, Qiqin Li, Yaoyao Li, Yun Wang, Yun-Feng Zhang
KEYWORDS:
Complete Congenital Stationary Night Blindness, Light-Deprivation, Electroretinogram, Oscillatory Potentials
JOURNAL NAME:
World Journal of Neuroscience,
Vol.6 No.3,
June
6,
2016
ABSTRACT: Current rodent models of
the complete congenital stationary night blindness (CSNB1) were time- consuming
in breeding and validation, which makes it imperative to find a more “easily
handle” animal model to broaden our understanding of this disorder. In the present
study, a light-deprivation (LD) mouse model was made to validate whether it was
a more “suitable” animal mode for investigating the pathogenesis of the CSNB1.
Compared with controls, the LD mice exhibited a remarkable reduction in the
amplitude of the dark-adapted electroretinogram (ERG) b-wave, the Max-ERG
b-wave and also the oscillatory potentials (Ops), indicating an abnormal
activity of rod bipolar cells in the retina. However, the ERG a-wave was
relatively normal in the LD mice, which was quite consistent with what was
confirmed in previously reported animal models of the CSNB1 and CSNB patients.
Taken together, the LD mouse model showed CSNB1-like negative ERG responses as
evidenced by the abnormal b-wave. Our study will provide a potentially useful
animal model to decipher the pathogenesis of the CSNB1.