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http://dx.doi.org/10.1074/jbc.M211996200

has been cited by the following article:

• TITLE: Effect of Hoechunyangkyeok-San Extract on Melanogenesis

  AUTHORS: Mi Jin Kim, Taek Kyu Jung, Hyun-Chul Park, Kyung-Sup Yoon

  KEYWORDS: Hoechunyangkyeok-San (Formula Extract Containing Forsythia viridissima Fruit, Platycodon grandiflorum Root, Glycyrrhiza glabra Root, Paeonia japonica Root, Angelica gigas Root, Scutellaria baicalensis Root, Gardenia jasminoides Fruit, Coptis chinensis Root, Mentha arvensis Leaf, Rehmannia glutinosa Root, Poncirus trifoliate Fruit), Melanogenesis, Melanosome Transport, Melanin, Whitening

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.6 No.3, May 26, 2016

  ABSTRACT: Forsythia fructus has been shown to have antioxidative, anti-inflammatory, antibacterial, anti-aging and whitening effects. Hoechunyangkyeok-san (Forsythia viridissima-prescription) is a traditional herbal medicine, which has been clinically used for treating febrile and inflammatory disorders. This work was carried out to investigate the skin whitening effects of Forsythia viridissima-prescription extract (a hydrolyzed extract of Hoechunyangkyeok-san: SID White HYC) on skin. The effects of SID White HYC were assessed the melanin contents in B161 melanoma cells and the pigmented equivalent with HMB45 and Fontana Masson staining in 3D skin model. Then, we examined the expression of major pigment enzymes regulating melanin synthesis and melanosome transport related proteins in B16F1 cells. SID White HYC significantly inhibited the melanin synthesis (56.7% and 30.6% inhibition at 100 μg/mL, intracellular and secreted, respectively) in B16F1 cells and 3D skin model. In addition, western blotting analysis showed that SID White HYC reduced the expression of melanin synthesis and melanosome transport related proteins in B16F1 cells. In clinical trials, the cream containing 0.05% SID White HYC showed skin depigmentation effect without any irritation. These results suggest that SID White HYC may be useful inhibition of melanogenesis and melanosome transport. Therefore, SID White HYC may have potential as a skin-whitening ingredient in cosmetics.