Article citationsMore>>
Martinez-Martin, P., Rodriguez-Blazquez, C., Abe, K., Bhattacharyya, K.B., Bloem, B.R., Carod-Artal, J., Dill, B., Esselink, R., Falup-Pecurariu, C., Gallardo, M., Mir, P., Naidu, Y., Nicoletti, A., Sethi, K., Tsuboi, Y., van Hilten, J.J., Visser, M., Zappia, M. and Chaudhuri, K.R. (2009) International Validation of the Non-Motor Symptoms Scale: Comparison with the Pilot Study. Neurology, 73, 1584-1591. http://dx.doi.org/10.1212/WNL.0b013e3181c0d416
has been cited by the following article:
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TITLE:
Effectiveness of Istradefylline for Fatigue and Quality of Life in Parkinson’s Disease Patients’ and of Their Caregivers’
AUTHORS:
Kazuo Abe, Masashi Fujita, Hiroo Yoshikawa
KEYWORDS:
Parkinson’s Disease, Non-Motor Symptoms, Istradefylline, Fatigue, Quality of Life, Caregivers
JOURNAL NAME:
Advances in Parkinson's Disease,
Vol.5 No.2,
May
18,
2016
ABSTRACT: Objectives: We evaluated efficacy and safety of istradefylline that is the first selective adenosine
A2A receptor antagonist, for the treatment of non-motor symptoms and quality of life (QoL) in
Parkinson’s disease (PD) patients with and QoL in their caregivers. Methods: This was a multisites
study of 40 PD patients (female 24, male 16) who fully filled UK PD society brain bank clinical
diagnostic criteria. They received istradefylline 20 mg/day for 8 weeks. We added istradefylline
on the previous anti-Parkinson’s drugs. Clinical severities were evaluated by Hoehn-Yahr (H-Y)
stage, unified PD rating scale (UPDRS), non-motor symptoms in PD (NMSPD), fatigue severity scale
(FSS) and Euro QoL. Also, we evaluated their caregiver’s QoL by Euro QoL. Results: The scores of
UPDRS part I improved from 1.3 ± 1.1 to 06 ± 0.9 (P = 0.18), part II improved from 11.9 ± 3.2 to
11.0 ± 3.1 (P = 0.17), part III improved from 34.8 ± 7.2 to 32.1 ± 8.3 (P = 0.105). There was no significant
improvement or worsening of the H-Y stages. The scores of NMSPD improved from 49.9 ±
11.2 to 43.9 ± 10.6 (P = 0.08). The scores of FSS improved from 62.8 ± 7.1 to 52.3 ± 9.3 (P = 0.049).
The total scores of Euro QoL in PD patients improved from 48.8 ± 14.9 to 57.2 ± 13.0 (P = 0.045).
The total scores of Euro QoL in patients’ caregivers improved from 54.2 ± 11.0 to 59.8 ± 10.9 (P =
0.046). Conclusions: Our data demonstrated that istradefylline was associated with few side effects
and was modestly effective for the treatment of non-motor symptoms especially fatigue that
might improve QoL in PD patients as well as in their caregivers’.
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