TITLE:
Study of Nanoskin ECM-Bacterial Cellulose Wound Healing/United Arab Emirates
AUTHORS:
Saqer Al Mualla, Raed Farahat, Pierre Basmaji, Gabriel Molina de Olyveira, Ligia Maria Manzine Costa, José Domingos da Costa Oliveira, Gino Bruno Francozo
KEYWORDS:
Bacterial Cellulose (Nanoskin), Natural Nanocomposites, Regenerative Medicine, Stem Cells
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.7 No.2,
April
29,
2016
ABSTRACT: Natural extracellular matrices (ECMs) perform the tasks necessary for tissue formation, maintenance,
regulation and function, providing a powerful means of controlling the biological performance
of regenerative materials. In addition, biomedical materials have claimed attention because
of the increased interest in tissue engineering materials for wound care and regenerative
medicine. Moreover, the nanostructure and morphological similarities with collagen make BC attractive
for cell immobilization, cell support and Natural Extracellular Matrix (ECM) Scaffolds. In
this work, we present the extracellular matrix (ECM) using the bacterial cellulose (Nanoskin®)
which regulates cell behavior by influencing cell proliferation, survival, shape, migration and differentiation.
Bacterial cellulose fermentation process is modified before the bacteria are inoculated
for mimicking ECM to cells support and built new local material for wound healing. Chemical
groups influences and thermal behavior in bacterial cellulose were analyzed using transmission
infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), respectively. Besides, In vivo analysis was evaluated with clinical study at Sharjah Kuwait Hospital.