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http://dx.doi.org/10.1107/S0021889807067908

has been cited by the following article:

• TITLE: Synthesis, Molecular Structure and Anti-Onchocercal Studies of 1-(Phthalazin-1(2H)-one)[(Pyridin-2-yl)ethylidene]hydrazone

  AUTHORS: Joseph N. Yong, Felicite Majoumo-Mbe, Moses Samje, Emmanuel N. Nfor

  KEYWORDS: Hydralazine Hydrochloride, Schiff Bases, Anti-Onchocercal Activity

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.6 No.1, March 30, 2016

  ABSTRACT: The novel ligand, 1-(phthalazin-1(2H)-one)[(pyridin-2-yl)ethylidene]hydrazone,(APN), derived from the antihypertensive drug, hydralazine hydrochloride, was synthesized and characterized by spectroscopic methods (IR, 1H NMR). The X-ray crystallographic data indicates that APN has an exocyclic C=N bond on the hydralazine moiety. APN revealed significant anti-onchocercal activity with IC50 values of 0.3125 μg/mL on microfilaria and 10 μg/mL on adult worms compared to the standard drug, ivermectin.