TITLE:
Association between Hyperglycemia, C-Reactive Protein and Other Risk Factors in Patients at Cardiovascular Risk
AUTHORS:
Sandra Maria Barbalho, Ricardo José Toffano, Marcelo Dib Bechara, Karina Rodrigues Quesada, Marie Oshiiwa, Claudemir Gregório Mendes, Marcia Rocha Gabaldi
KEYWORDS:
Hyperglycemia, C-Reactive Protein, Angiography, Castelli Index, Lipids
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.6 No.1,
February
4,
2016
ABSTRACT: Type 2 diabetes (DM2) is a syndrome characterized by postprandial
hyperglycemia normally due to peripheral resistance to insulin and accounts for
approximately 90% of diabetes cases worldwide and it is usually related to
dyslipidemia, overweight/obesity and physical inactivity and increase in the
risk of cardiovascular disease. This study aimed to compare the metabolic and inflammatory
profile of hyperglycemic with non-hyperglycemic subjects in a group of patients
undergoing coronary arteriography. Our group of patients showed that 63.16%
presented glycaemia above 99 mg/dL (from the hyperglycemic patients, 31
individuals were classified as glucose intolerant and 29 as diabetic).
Significant differences were found for glycaemia, LDL-c (Low Density
Lipoprotein), and hs-CRP (high sensitivity C reactive protein) levels.
Nevertheless it is possible to observe that patients with higher glycaemia
showed increased values of Total Cholesterol, Triglycerides, LDL-c, Castelli
Index I and II and estimative of LDL-c size particle and decreased HDL-c (High
Density Lipoprotein) values. The comparison between hs-CRP levels and
biochemical parameters shows significant differences for Body Mass Index,
Triglycerides, HDL-c and the estimative of LDL-c particle. Also, the presence
of Metabolic Syndrome is more prevalent in patients with high levels of hs-CRP.
Diabetes patients have more significant increase in morbidity and mortality
than the general population frequently due to further complications associated
with the resistance to insulin. It is indispensable to outline the
anthropometric and biochemical profile from hyperglycemic patients in order to
work on secondary prevention of cardiovascular disease.