McLeod, R.L., Rizzo, C.A., West Jr., R.E., Aslanian, R., McCormick, K., Bryant, M., Hsieh, Y., Korfmacher, W., Mingo, G.G., Varty, L., Williams, S.M., Shih, N.Y., Egan, R.W. and Hey, J.A. (2003) Pharmacological Characterization of the Novel Histamine H3-Receptor Antagonist N-(3,5-dichlorophenyl)-N’-[[4-(1H-imidazol-4-ylmethyl)phenyl]- methyl]-urea (SCH 79687). The Journal of Pharmacology and Experimental Therapeutics, 305, 1037-1044.
http://dx.doi.org/10.1124/jpet.103.049254

has been cited by the following article:

• TITLE: Imetit Dihydrobromide and Thioperamide Medication in Cough Hypersensitivity Model—The Role of H3 Receptors

  AUTHORS: Tomas Buday, Eva Kovacova, Silvia Gavliakova, Natalia Kavalcikova-Bogdanova, Martina Antosova, Jana Plevkova

  KEYWORDS: Chronic Cough, Allergic Rhinitis, Histamine, Antitussive, Imetit, Thioperamide, H3 Receptor

  JOURNAL NAME: Open Journal of Molecular and Integrative Physiology, Vol.6 No.1, February 4, 2016

  ABSTRACT: Chronic cough is a troublesome problem and it is frequently associated with diseases such as gastroesophageal reflux, asthma and upper airway diseases—so called diagnostic triade. The magnitude and severity of cough is strongly associated with the ongoing nasal inflammation in subjects with rhinosinusitis and treatment of nasal inflammation leads to the down regulation of pathologically up-regulated cough. Histamine plays a key role in the inflammation of the upper airways of different aetiologies; therefore histamine receptors seem to be promising targets. The aim of our study was to ascertain the effect of H3R agonist imetit and H3R antagonist thioperamide on cough and symptoms of allergic rhinitis (AR) in an animal model of upper airway cough syndrome in ovalbumin sensitized guinea pigs. OVA sensitized guinea pigs (n = 10) were repeatedly challenged with i.n. allergen-OVA to induce allergic rhinitis and to enhance cough reflex according to the validated model of experimental allergic rhinitis. Animals were pre-treated by i.p. administration of imetit (1 mg/kg and 2 mg/kg of body weight) and thioperamide 30 min. prior i.n. OVA administration. Rhinitis evaluation was based on the occurrence of typical symptoms. The effect on cough was assessed from the response to inhalation of citric acid (0.4 M, 10 min), final cough count and cough latency were analysed from the airflow traces, cough motor pattern and the cough sound. AR up-regulated the cough response from 9 ± 2 to 16 ± 1 cough per provocation, med ± IQR, p