TITLE:
Primary Ovarian Non-Hodgkin’s Lymphoma: Retrospective Study of 16 Patients
AUTHORS:
Hala Aziz Shokralla, Ahmed Elsayed Fathalla, Nevine F. H. Sidhom
KEYWORDS:
Ovary, Primary Non-Hodgkin’s Lymphoma, Report, Outcome
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.7 No.1,
January
28,
2016
ABSTRACT: Background: Primary non-Hodgkin’s lymphoma (PONHL) of the ovary is rare disease.
Ovarian involvement by NHL is usually secondary, as a part of systemic disease.
It is frequently diagnosed as ovarian carcinoma which causes a significant delay
in diagnosis and management. Objective: To analyze, to report and to better understand
the clinico-pathologic features and results of treatment, and prognostic factors
of these tumors. Material & methods: This was a retrospective single institutional
work that included 16 cases of primary ovarian non-Hodgkin lymphoma (PONHL) treated
in National Cancer Institute-Cairo University from January 2010 till January 2015.
All available medical data including the clinical and pathological characteristics,
treatment, and outcomes of patients with PONHL are analyzed. Results: Data from
16 patients are obtained. The patient’s age ranges from 14 to 55 years (mean 28
years). Ascites is the most common manifestation (75%). Tumor size ranges from 5
to 24 cm (mean 13.1). LDH is elevated in all cases (mean 644 U/L) and CA-125 is
elevated in only 4 cases (25%) especially when there is an extensive peritoneal
irritation. Ten cases (62.5%) are bilateral with stage IV-E according to the Ann
Arbor staging system. The remaining six cases (37.5%) are unilateral with Ann Arbor
stage I-E. There are no stage II-E or III-E in the current study. Tumors are classified
according to the World Health Organization as follows: diffuse large B-cell lymphoma
(10 cases) (62.5%), Burkitt’s lymphoma (5 cases) (31%) and only one case of B-lymphoblastic
lymphoma/leukemia. All the tumors are of B-cell lineage and are all CD20 positive.
All Burkitt’s lymphoma cases show higher Ki67 index (4 cases are 100% and one is
88%). The case of B-lymphoblastic lymphoma/leukemia is positive for TDT & CD
10. Surgery is the main treatment modality for primary diagnosis and for staging,
although chemotherapy should have been the primary treatment because it is one of
the most chemosensitive tumors. Follow-up period
ranges from 3 months to 5 years (mean 33 months). Ten patients are alive without
disease. Two cases experienced relapse and one case died during chemotherapy treatment.
The remaining three cases died from other causes than disease. The median overall
survival time was not reached yet; however, the mean overall survival was 46.8 monthes;
median progression free survival was 36 months. Conclusion: Most patients with PONHL
present with symptoms attributable to an ovarian mass which necessitates
extensive surgical staging that is not mandatory for lymphomas. More studies will
be needed to better define and treat this rare entity.