TITLE:
Synapsin Polymorphisms Could Be Correlated with Stroop Simple Reaction Time Scores
AUTHORS:
Ahmet Buber, Burge Kabukcu Basay, Omer Basay, Onder Ozturk, Huseyin Alacam, Kemal Utku Yazici, Ali Bacanli, Mustafa Ertan Ay, Mehmet Emin Erdal, Hasan Herken, Eyup Sabri Ercan
KEYWORDS:
Attention Deficit Hyperactivity Disorder, Synapsin III, Association, Cognitive Function
JOURNAL NAME:
American Journal of Molecular Biology,
Vol.6 No.1,
January
6,
2016
ABSTRACT: Objective: The aim of this study was to research the relationship between Attention Deficit Hyperactivity
Disorder (ADHD) and the synapsin III -196G>A and -631C>G polymorphisms and study
their impact on neurocognition and behavior in Turkish children and adolescents. Methods: A total
of 201 ADHD-diagnosed children and 100 control subjects aged between 8 and 15 years were
recruited, and genetic material was obtained from saliva. In the diagnostic assessments, the KSADS-
PL semi-structured interview was applied. Children with any comorbid psychiatric diagnosis
(with the exclusion of oppositional defiant disorder (ODD)), medical conditions, prior psychotropic
drug use history or IQ score below 80 were excluded. For the behavioral and ADHD symptom
assessments, the Turgay DSM-IV Disruptive Behaviors Rating Scale, Teacher Report Form (TRF)
and Child Behavior Checklist (CBCL) were completed by the parents and teachers. Neurocognitive
profiles were evaluated with the CNS-Vital Signs computerized neurocognitive test battery. Results:
No significant difference in ADHD prevalence was observed between subjects with the synapsin III
gene -196G>A polymorphism and -631C>G polymorphisms. These polymorphisms were also not
associated with subtypes of ADHD. We found a relationship between both polymorphisms and Stroop simple reaction time. Conclusion: Synapsin’s effect could be limited during childhood, but
synapsin polymorphisms could be associated with Stroop simple reaction time.