TITLE:
Prevalence of Isolated “Pre-Malignant” Lesions on Prostate Biopsy in a Racially Diverse Community Screened Cohort
AUTHORS:
Michael A. Liss, Donna Ankerst, David Zapata, Javier Hernandez, Robin J. Leach, Ian M. Thompson
KEYWORDS:
Active Surveillance, Ethnicity, Prostate Biopsy, Prostate Cancer, Race
JOURNAL NAME:
Open Journal of Urology,
Vol.5 No.12,
December
17,
2015
ABSTRACT: Objective: We investigated rates of
prostate cancer (PCa), high-grade prostatic intraepithelial neoplaisa (HGPIN)
and atypical small acinar proliferation (ASAP) in a multiethnic cohort.
Methods: We evaluated prostate biopsy outcomes in men enrolled in the San
Antonio Center of Biomarkers of Risk for prostate cancer (SABOR) prospective,
observational study. PCa-free men underwent annual PSA testing over nearly 14
years with biopsies based on community standards. We investigated biopsy
outcomes with a special interest in rates of cancer, HGPIN, and ASAP. Results:
We identified 975 prostate biopsies in 801 subjects from 3/1/2001 to 1/9/2014.
PCa, HGPIN, or ASAP was encountered in 28.8% (281/975), 10.1% (98/975), and
5.2% (51/975) of prostate biopsy specimens, respectively. The most significant
risk factor for a PCa diagnosis was African American race (OR 5.0, 95% CI: 2.2
- 11.4, p