TITLE:
Frozen Section in Postmenopausal Women Presented with Suspicious Ovarian Masses, Does It Have a Role?
AUTHORS:
Basel Refky, Anas Gamal, Emad Hamed, Adel Fathi, Mohammad Arafa, Sameh Roshdy, Khaled Gaballa, Essam Attia, Mohamed Abdelkhalek, Mohamed T. Hafez, Fayz Shahatto, Shadi Awny, Doaa Shokry, Gehad Tawfik
KEYWORDS:
Frozen Section, Ovarian Cancer, Surgical Staging
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.14,
December
10,
2015
ABSTRACT: Background: Frozen section (FS) has a valuable role in the diagnosis of
ovarian tumors. It is considered a pivotal point in guiding the surgical
therapy, particularly in premenopausal women. In postmenopausal women, it may
be required as well to avoid unnecessary surgical staging in benign ovarian
tumors. Aim: This study aims to evaluate the accuracy of intraoperative frozen
section in ovarian neoplasms in postmenopausal women. Materials and Methods: A
retrospective analysis was done for intraoperative FS for suspected ovarian
neoplasms. The study was conducted in Oncology Center, Mansoura University from
March 2008 to December 2014. The frozen and paraffin section reports were
compared, and overall accuracy, sensitivity, specificity, positive and negative
predictive values were determined. Results: The study included 105 patients and
the overall accuracy of FS in determining malignancy was 81.7%. The sensitivity
for malignant tumors was 75.32% with
specificity of 100%. For benign tumors, the sensitivity and specificity were
100% and 93%, respectively. Borderline tumors had the lowest sensitivity
of 100% with specificity of 95.19%. Conclusion: The present study concurs that
frozen section is an accurate test for diagnosis of benign and malignant tumors
in postmenopausal women thus determining the extent of surgery done for them.
On the other hand, accuracy rates for borderline tumors are low.