TITLE:
Inter-Toe Cracks: A Cosmetic Response versus Excipient. Efficacy and Tolerance Evaluation
AUTHORS:
Adeline Jeudy, Thomas Lihoreau, Ferial Fanian, Rafat Messikh, Christine Lafforgue, Philippe Humbert
KEYWORDS:
Formulation, Laminin 5, Inter-Toe Cracks, Healing Process, Double-Blind Clinical Study
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.5 No.4,
December
1,
2015
ABSTRACT: A randomized, monocentric, double-blind, intra-individual
excipient-controlled comparative study was performed to evaluate the efficacy
and tolerance of an active peptide (laminin 5 fragment [LN-5]) formulated in
cosmetic balm, versus excipient in inter-toe cracks. Two products were tested
on 10 healthy volunteers. Each of them suffered from this particular
superficial wound characterized by a peeling off a skin tab between at least
two inter-toe spaces. The duration of this study belonged of 28 days with an
intermediate visit to D14. Initial and outcome evaluation was performed using a
4-grade-scale depending on the severity of the inter-toe cracks. Tolerance and
healing were assessed using macrophotographs. At D14 and D 28, the difference
of cure between the 2 treatments was in favor of the peptide active product. The
clinical score showed a best efficiency of the active compared with the
excipient; indeed a significant difference between D28 and D0 was observed for
the active ingredient. Active product repairs more quickly inter-toes cracks
than the excipient and we noted the complete disappearance of the “severe” and “moderate”
stages from the 14th day. This study showed clearly a fast (in 14
days) and beneficial effect of the application of LN-5 compared with the
excipient, on the cutaneous repair of inter-toes cracks. Since LN-5 fragment is
capable of producing immediate biological activity and reinforcing the dermal-epidermal
junction, it can accelerate tissue repair.