TITLE:
Use of Human Embryonic Stem Cells in the Treatment of Diabetes Mellitus: A Case Series
AUTHORS:
Geeta Shroff
KEYWORDS:
Diabetes, hESC Therapy, iPSCs
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.5 No.4,
November
23,
2015
ABSTRACT: Introduction: Diabetes mellitus (DM), a metabolic
disorder, is known to be highly prevalent in people aged 40 - 60 years in developing countries whereas in developed
countries, it mostly affects people above the age of 60 years. It is of two
types: DM type I, an autoimmune disorder that mostly onsets after an infection
and DM type II that is commonly associated with obesity. Several treatments are available for the treatment of DM,
but none has successfully cured diabetes. Nowadays, stem cell therapy is
being investigated for use in the treatment of DM and has shown positive
results. Case Report: Our study presented results of three diabetic patients
who were treated with human embryonic stem cell (hESC) therapy. Following the
therapy, blood glucose levels were reduced. An improvement was observed in eye
sight, stamina, gait pattern endurance, mental focus ability and muscle
strength. There was a reduction in secondary side effects of high blood sugar
such as affectation of cardiac, kidneys, polyneuropathy, vision etc. No adverse
events and teratoma formation were observed
after the treatment. Conclusion: It was concluded that hESCs showed good
therapeutic potential in the treatment of patients with diabetes.