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http://dx.doi.org/10.1016/j.burns.2008.05.016

has been cited by the following article:

• TITLE: Serum and Blister Fluid Pharmacokinetics of Amikacin in Severe Burn Patients

  AUTHORS: Rong Hua, Hongliang Xu, Xinzhou Rong, Ronghua Yang

  KEYWORDS: Amikacin Pharmacokinetics, Blister Fluid, Serum, Severe Burn Patients

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.6 No.11, November 23, 2015

  ABSTRACT: Objective: To characterize amikacin pharmacokinetics in serum and in blister fluid of severe burn patients to guide optimal treatment timing. Methods: Patients (N = 32) were divided into four groups based on amikacin administration timing and groups received drug minutes to hours after injury. In Groups A, B, C, and D, amikacin (400 mg, IV) was administered 3 - 4, 10, 20 and 30 h post burn injury, respectively (N = 8 for all groups). Next blister fluid and venous blood samples from 9 patients were obtained at 0, 0.25, 0.5, 1, 2, 3, 4, 5, 6, and 7 h after drug infusion. Amikacin concentrations were measured with a fluorescent polarization immunoassay and pharmacokinetics was deduced using DAS3.2.5. Statistical analyses performed with SPSS13.0. Results: Compared with normal values, t1/2z of amikacin from burn patients was shortened in serum but amikacin half-lives in blister fluid was significantly greater than serum half-life values (p