Sriram, D., Yogeswari, P. and Reddy, S. (2006) Synthesis of Pyrazinamide Mannich Bases and Its Antitubercular Properties. Bioorganic & Medicinal Chemistry, 16, 2113-2116.
http://www.ncbi.nlm.nih.gov/pubmed/16464574
http://dx.doi.org/10.1016/j.bmcl.2006.01.064

has been cited by the following article:

• TITLE: Synthesis of New Mannich Products Bearing Quinoline Nucleous Using Reusable Ionic Liquid and Antitubercular Evaluation

  AUTHORS: Hitendra M. Patel

  KEYWORDS: Antitubercular Activity, Green Synthesi, Mannich Products, Mycobacterium tuberculosis, Quinoline, Spectroscopic Tools

  JOURNAL NAME: Green and Sustainable Chemistry, Vol.5 No.4, November 16, 2015

  ABSTRACT: A series of Mannich products bearing quinoline nucleus was synthesized, characterized, and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. The results showed that compounds 4b, and 4d found most active with percentage inhibition of 95, and 96, respectively, at minimum inhibitory concentration (MIC) of >6.25 μg/mL, among the synthesized compounds. Whereas, compounds 4a, 4c, 4e, and 4f exhibited considerable antitubercular activity with percentage inhibition of 71, 79, 55, and 68, respectively, at MIC of >6.25 μg/mL. The structures of synthesized compounds were elucidated by various spectroscopic tools like IR, 1H NMR, 13C NMR, mass and elemental analysis.