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Russell, M.G., Carling, R.W., Street, L.J., Hallett, D.J., Goodacre, S., Mezzogori, E., Reader, M., Cook, S.M., Bromidge, F.A., Newman, R., Smith, A.J., Wafford, K.A., Marshall, G.R., Reynolds, D.S., Dias, R., Ferris, P., Stanley, J., Lincoln, R., Tye, S.J., Sheppard, W.F., Sohal, B., Pike, A., Dominguez, M., Atack, J.R. and Castro, J.L. (2006) Discovery of Imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 Subtype Selective Agonists for the Treatment of Anxiety. Journal of Medical Chemistry, 49, 1235-1238.
http://dx.doi.org/10.1021/jm051200u
has been cited by the following article:
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TITLE:
Synthesis of Fluorinated Heterobicyclic Nitrogen Systems Containing 1,2,4-Triazine Moiety as CDK2 Inhibition Agents
AUTHORS:
Mohammed Saleh Tawfik Makki, Reda Mohammdy Abdel-Rahman, Faisal Mohammed Aqlan
KEYWORDS:
Synthesis, Fluoroheterobicyclic Nitrogen, CDK2 Inhibition, Anti-Tumor Activity
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.5 No.3,
September
28,
2015
ABSTRACT: New fluorine substituted heterobicyclic nitrogen system as imidozolopyrimidines (2,3), pyrimido- 1,2,4-triazinones (4-7), 1,2,4-triazinyl-1,2,4-triazine (12-16), 1,2,4-triazinyl-1,2,4-triazinones (14-17) and substituted thiobarbituric acids (19-20), have been synthesized using the reaction of 3- amino-5,6-di (4'-fluorophenyl)-1,2,4-triazine (1) with α,β–bifunctional compounds. Structures of the title compounds were characterized by UV, IR, 1H/13C-NMR and mass spectrometric method. The studied compounds were tested for CDK2 inhibiting activity in DNA damage, as well as in vitro anti-tumor activity.