TITLE:
Datura metel Administration Distorts Medial Prefrontal Cortex Histology of Wistar Rats
AUTHORS:
Temitope Akhigbe Etibor, Musa Iyiola Ajibola, Mohammad Olanrewaju Buhari, Abass Alao Safiriyu, Oluwole Busayo Akinola, Ezekiel A. Caxton-Martins
KEYWORDS:
D. metel, Nissl Substance, Prefrontal Cortex, Chromatolysis
JOURNAL NAME:
World Journal of Neuroscience,
Vol.5 No.4,
July
31,
2015
ABSTRACT: Datura metel is one of
psychoactive substances of great ethno-pharmacological significance often
abused because of its unrestricted availability, yet, little is known about its
mechanisms of action. This work was therefore aimed at assessing the activity
of ethanolic seed extract of D.
metel on Nissl substances,
astrocytes, axonal and neuronal integrity of the medial prefrontal cortex
(mPFC) of Wistar rats. Eighteen Wistar rats averaging 175 g were used and
randomly assigned to three groups: group A rats (n = 6) were administered
extract of 100 mg/kg bw, group B rats (n = 6) received extract of 200 mg/kg bw,
and group C-control (n = 6) took distilled water only for 14 days. The results revealed
that D. metel is deleterious to the health of
Wistar rats at a dose-dependent rate
as observed in its actions on the medial prefrontal cortex at 100 mg/kg bw and
200 mg/kg bw. The histological
study of the treated Wistar rats exhibited features of disoriented neuronal
integrity such as, chromatolysis, reduced protein synthesis due to loss of
Nissl substances and nuclei, neuronal loss as well as axonal injuries.