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has been cited by the following article:

• TITLE: Expression of Multidrug Resistance ATP-Binding Cassette (ABC) Transporters in Canine Mammary Tumors

  AUTHORS: Breno S. Salgado, Suely Nonogaki, Luisa M. Soares, Angela Akamatsu, Cristiano R. N. da Silva, Thiago P. Anacleto, Rodolfo Malagó, Rafael M. Rocha, Fátima Gärtner, Noeme S. Rocha

  KEYWORDS: MDR1, P-Gp, MRP1, MRP2, ABCC2, Mammary Neoplasms, Prognosis, Dog

  JOURNAL NAME: Advances in Breast Cancer Research, Vol.4 No.3, July 29, 2015

  ABSTRACT: Mammary neoplasms are the most common tumors in female dogs. They are usually treated using solely surgical mastectomy—which is recognized as unsatisfactory in many cases. Given this, the benefits of chemotherapy in dogs with mammary cancer need to be further explored. Some drugs that can be used for treating canines with mammary tumors may be substrates of uptake and/or efflux transporters such as the ATP-binding cassette (ABC) transporters. Unfortunately, very little is known regarding the pathobiology of such proteins in canine tumors, including mammary cancer. Accordingly, this study was designed to characterize the expression of ABC transporters P-glycoprotein, MRP1, and MRP2 and their relation with clinicopathologic factors in order to allow a better understanding of their influence in canine mammary cancer. P-glycoprotein was expressed in tumors from 55.8% of patients, while MRP1 and MRP2 were expressed in 37.2% and 39.5% of tumors, respectively. P-glycoprotein expression showed to be related with regional lymph node spread (P = 0.0038), as well as with tumor grade (P = 0.0353) and with a shorter survival (P = 0.0245). MRP1 revealed a strong association with a higher histological grade (P