Article citationsMore>>
Rixe, O., Bukowski, R.M., Michaelson, M.D., Wilding, G., Hudes, G.R., Bolte, O., Motzer, R.J., Bycott, P., Liau, K.F., Freddo, J., Trask, P.C., Kim, S. and Rini, B.I. (2007) Axitinib Treatment in Patients with Cytokine-Refractory Metastatic Renal-Cell Cancer: A Phase II Study. Lancet Oncology, 8, 975-984.
http://dx.doi.org/10.1016/S1470-2045(07)70285-1
has been cited by the following article:
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TITLE:
Efficacy and Safety of Axitinib as First-Line Therapy in Japanese Patients with Metastatic Renal Cell Carcinoma
AUTHORS:
Takeshi Namekawa, Satoshi Fukasawa, Atsushi Komaru, Masayuki Kobayashi, Takayuki Ohzeki, Yosuke Sato, Junryo Rii, Hirotsugu Uemura, Tomohiko Ichikawa, Takeshi Ueda
KEYWORDS:
Axitinib, Renal Cell Carcinoma, First Line
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.8,
July
28,
2015
ABSTRACT: Previous study
reported that patients treated with axitinib as second-line therapy had longer
median progression-free survival than those treated with sorafenib for
metastatic renal cell carcinoma (mRCC). In this study, we reviewed our
experience of axitinib as a first-line therapy for mRCC in Japanese patients,
focusing on its efficacy and safety. We retrospectively assessed 26 patients
treated with axitinib as a first-line therapy for mRCC from July 2010 to July
2014 at Chiba Cancer Center and Kinki University Hospital. Observation period
was 24.6 ± 18.3 months. The objective response rate was 50.0%, and the median
progression-free survival was 27.5 months. Overall survival was not estimable.
Common grade 3 adverse events were hypertension in 19 patients and proteinuria
in 5 patients. Axitinib demonstrated significant efficacy as a first-line therapy
in Japanese patients with mRCC. Careful monitoring and management of the
adverse effects may help to control its toxicities.
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