TITLE:
Nano-Coupling of Cephalosporin Antibiotics with Fe3O4 Nanoparticles: Trojan Horse Approach in Antimicrobial Chemotherapy of Infections Caused by Klebsiella spp.
AUTHORS:
Ulviyya Alimammad Hasanova, Mahammadali Ahmad Ramazanov, Abel Mammadali Maharramov, Qoncha Malik Eyvazova, Zohrab Adalet Agamaliyev, Yana Vacheslav Parfyonova, Sarvinaz Faiq Hajiyeva, Flora Vidadi Hajiyeva, Solmaz Bayram Veliyeva
KEYWORDS:
Magnetite Nanoparticles, Cephalosporin, Cefotaxime, Ceftriaxone Klebsiella, Staphylococcus aureus
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.6 No.3,
July
22,
2015
ABSTRACT: In the present study we had an aim to develop the methods of functionalizing the surface of magnetite
nanoparticles with cefotaxime and ceftriaxone antibiotics. The quantitative analysis of the
nanostructured cephalosporins was determined by Atom Absorbance Spectroscopy (AAS) and
based on the Lambert-Beer law. The engineered nanostructures were tested on gram-negative
microorganisms Klebsiella spp., of Enterobacteriaceae, and gram-positive bacteria Staphylococcus aureus, each having multi-drug resistance properties.