TITLE:
Is Premenstrual Syndrome a Uterine Inflammatory Disease? Retrospective Evaluation of an Etiologic Approach
AUTHORS:
Jorge Lolas-Talhami, Juana Lafaja-Mazuecos, Diego Ferrández-Sempere
KEYWORDS:
Premenstrual Syndrome, Premenstrual Dysphoric Disorder, Inflammatory Cytokines, Cervix Injections, Cervix Cryotherapy
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.5 No.6,
June
3,
2015
ABSTRACT: Objective: To retrospectively evaluate the
efficacy of local uterine antibiotic and anti-inflammatory injections combined
with cryotherapy for the treatment of severe Premenstrual Syndrome (PMS) and
Premenstrual Dysphoric Disorder (PMDD). To validate the hypothesis of a uterine
infectious/inflammatory etiology of PMS/PMDD. Methods: Clinical files of 161
women sequentially treated from September 1995 to April 2005, were collected
for study. A subset of 148 patients (mean: 36.7 ± 7.8 years, range: 20.1 - 53.8
years) were eligible for statistical analysis. The ten most relevant PMS
symptoms, namely depression, irritability, anxiety, fatigue, headache, edema,
breast tenderness, abdominal bloating, pelvic pain and dysmenorrhea, were
self-rated before and three menstrual cycles after treatment, using a 0 to 5
scale. The treatment consisted of cervical stromal antibiotic/anti-inflammatory
injections combined with intracervical cryotherapy. Scores were compared using
non-parametric tests for matched samples. Results: Before treatment, mean
severity scores for the 10 symptoms were 3.97 ± 1.17, 4.26 ± 0.88, 3.41 ± 1.23,
3.91 ± 0.94, 3.35 ± 1.71, 2.28 ± 1.69, 2.13 ± 1.63, 4.51 ± 0.63, 2.28 ± 1.30, and
2.28 ± 1.88, respectively. Mean values after treatment were 0.54 ± 0.91, 0.51 ±
0.91, 0.32 ± 0.70, 0.42 ± 0.74, 0.43 ± 0.96, 0.22 ± 0.53, 0.39 ± 0.73, 1.01 ±
0.94, 0.28 ± 0.69, and 0.44 ± 0.92. All tests were statistically significant (p