Marko, A.J., Miller, R.A., Kelman, A. and Frauwirth, K.A. (2010) Induction of Glucose Metabolism in Stimulated T Lymphocytes Is Regulated by Mitogen-Activated Protein Kinase Signaling. PLoS ONE, 5, e15425. http://dx.doi.org/10.1371/journal.pone.0015425

has been cited by the following article:

• TITLE: Modifications of L-Glutamine and L-Leucine Transport in Proliferating Lymphocytes

  AUTHORS: Francisco Sanchez, Jose Luis Gil, Macarena Perán

  KEYWORDS: Cell Membrane Transport, Lymphocytes, L-Glutamine, L-Leucine, Malignancy Biomarkers

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.3 No.3, March 31, 2015

  ABSTRACT: Lymphocytes respond to mitogens that stimulate proliferation by increasing theirs metabolic activity. In this study we investigate L-Glutamine and L-Leucine uptake as markers of cell response to Concavalina A (ConcaA) stimulation, using a high-resolution flow technique. We found that lymphocytes induced to blast transformation enhanced rate and efficiency of amino acid uptake during cell proliferation. Considering that increases in transport is the first quantifiable response of cells during malignant transformation, amino acid uptake could also be useful as an early marker of malignancy.