TITLE:
The Role of Antioxidant Vitamin C on Imminent Abortion through Interaction of Superoxide Dismutase, Interferon-γ, Interleukin-4, Vascular Cells Adhesion Molecule-1, and Decidual Spiral Arteries Blood Flow
AUTHORS:
Budi Handono, Firman F. Wirakusumah, Johanes C. Mose, Tri Hanggono Achmad
KEYWORDS:
Imminent Abortion, SOD, VCAM-1, IFN-γ, IL-4, DSA RI
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.5 No.2,
February
13,
2015
ABSTRACT:
Imminent abortion needs more serious attention since it remains a
big problem in Indonesia considering its epidemiology, morbidity,
mortality,and prognosis. In fact, some cases can still be
prevented.The objective of this study was to determine pathogenesis,
diagnosis,and prognosis of imminent abortion through the role of
antioxidant vitamin C in the interaction of superoxide dismutase (SOD),
interferon-γ(IFN-γ), interleukin-4 (IL-4), vascular cells adhesion
molecule-1(VCAM-1), and decidual spiral artery resistance index (DSA
RI).This study took 10 months from March to December 2007 at Obstetrics
and Gynecology Department of Medical Faculty
ofPadjadjaranUniversity/Hasan Sadikin Hospital, Bandung. Sixty
pregnant women who met the inclusion and exclusion criteria were divided into
two groups with the random clinical trial method, double-blind withrepeated
measurements.Data were analyzed statistically using t test, Mann-Whitney,
RankSpearman, Wilcoxon, t paired, and diagnostic test.The results
of this study showed that the incidence of abortion in vitamin C group was 9
cases (30%) and placebo group was 13 cases (43.3%). There was a significant
difference in SOD, IFN-γ, IL-4 and VCAM-1 level between groups of women
with and without abortion (p ￡992 U/gHbwhichshowed quite high sensitivity,
specificity, accuracy,and significant difference (p γ, VCAM-1 and DSA RI (p γlevel
andtheincrease of IL-4 level in imminent abortion after vitamin C
administration. Therewas a correlation betweentheincrease of
SOD level withthedecrease of DSA RI andthedecrease of
VCAM-1 level in imminent abortion after vitamin C administration. In abortion,
therewasadecrease of SOD and IL-4 level,as well as
anincrease of IFN-γ,
VCAM-1, and DSA RI level.