TITLE:
Multiple Detector-Row CT in Gastric Cancer Staging: Prospective Study
AUTHORS:
Lorenzo Bruno, Lucia Barni, Gaia Masini, Sabrina Pacciani, Edvige Lucarelli, Antonella Masserelli, Daniela Tomcykova, Filippo Melli, Luca Boni, Giancarlo Freschi, Paolo Bechi
KEYWORDS:
Gastric Cancer, MDCT, Staging, Oncologic Imaging
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.14,
December
25,
2014
ABSTRACT:
The aim of this study was to evaluate the
accuracy of multiple detector computed tomography (MDCT) in the preoperative
staging of gastric cancer, prospectively comparing CT findings with
pathological findings at surgery, in a single-center study. A total of 19
consecutive patients with primary cancer recruited between March and July 2014
were submitted to preoperative MDCT staging according to a standard protocol.
All diagnostic procedures were performed by dedicated radiologists who were
unaware of the final pathological results. Subsequently, 16 patients underwent
surgical treatment and 15 were finally included in the study. The primary tumor
was detected at CT in all 15 cases. CT results for T staging were in agreement
with pathological findings in 12 of 15 cases, with overall accuracy of 80%.
Stage-specific sensibility was high for advanced stages (sensibility for T1,
T3, and T4 resulted 60%, 85.7%, and 100%, respectively),
while earlier stages showed higher specificity (specificity for T1, T3, and T4
resulted 100%, 75%, and 91.7%, respectively). Overall N staging accuracy was
86.7%, with 13 of 15 patients correctly staged. Stage-specific sensibility was
75% for N0 and 100% for N3, while specificity was 100% for N0 and lower for
advanced stages. Accuracy for peritoneal involvement was 100%. Our findings
show a good performance of the diagnostic protocol performed with MDCT tested
in this study.