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has been cited by the following article:

• TITLE: Quantitative EEG Changes in Patients with Parkinson’s Disease during Therapy with Rasagiline

  AUTHORS: Wilfried Dimpfel, Christian Oehlwein, Josef Anton Hoffmann, Thomas Müller

  KEYWORDS: Rasagiline, Selegiline, Quantitative EEG, CATEEM®, Parkinson’s Disease, Cognition

  JOURNAL NAME: Advances in Parkinson's Disease, Vol.3 No.3, August 28, 2014

  ABSTRACT: It has been suggested that in patients with Parkinson’s disease (PD) metabolism of the MAO-B inhibitor selegiline to methamphetamine may contribute and/or exacerbate sleep problems, possibly leading to deficits of cognition. This open-label exploratory study included 30 PD patients currently being treated with selegiline (7.5 mg/day) and complaining of sleep disturbances. The aim of the study was to determine whether switching from selegiline to another MAO-B inhibitor without amphetamine-like metabolites, namely rasagiline, would improve sleep behaviour and cognitive function in PD patients. Pathologic aberrations as determined by comparison of the frequency pattern of patients to a database consisting of healthy subjects revealed an approximation of electric brain activity to normality. For verification of efficacy, a combination of questionnaires, quantitative source density EEG recording with CATEEMò and performance of two psychometric tasks (d2-test of attention and reading) during the EEG recording were done on the last day of selegiline treatment (7.5 mg/day) as well as 2 and 4 months later, during which the patients were treated with rasagiline (1 mg/day). In addition, performance of the mental tasks revealed a statistically significant (p