TITLE:
Increasing Prevalence of Osteoporosis, Hypothyroidism and Endogenous Estrogen with Germ Cells
AUTHORS:
Elizabeth Jeya Vardhini Samuel, Nagarajan Natarajan, Sivakumar Periasamy, Joseph Vimal, Sanjoy George, Gouthaman Thiruvenkadam
KEYWORDS:
Contraception Reversal, Smashed Fragmentation of Germ Cells, Reduced Endogenous Estrogen, Germ Cells Replant Effect
JOURNAL NAME:
Open Journal of Rheumatology and Autoimmune Diseases,
Vol.4 No.3,
August
5,
2014
ABSTRACT:
Background: Women were expressing disabling low back aches and weight gain attributing to puerperal sterilization, when contraception implementation as Family Welfare Program was progressing between ~1983 and ~1989. Hence we sought to identify any correlation existing with contraception. Methods: We performed a retrospective analysis of prevalence of osteoporosis and hypothyroid status, in 350 patients of 20-35 years, 35-50 years, >50 years age groups, from data collected by convenient, stratified random sampling of different geographical locations, between 1995-2012. We also analyzed its association with presence or absence of contraception and abortion. Simultaneously, serum estrogen levels obtained from 105 patients were also analyzed. Results: ~15-25 fold increase in osteoporosis was seen in contraceptive users with a p value of 20->50 years age group; we also found a 6 fold increase in hypothyroidism among contraceptive users aged >35 years [p 20 years age group [p 50 years age group [p