Zimmer, A., Bouley, J., Le Mignon, M., Pliquet, E., Horiot, S., Turfkruyer, M., Baron-Bodo, V., Horak, F., Nony, E., Louise, A., Moussu, H., Mascarell, L. and Moingeon, P. (2012) A Regulatory Dendritic Cell Signature Correlates with the Clinical Efficacy of Allergen-Specific Sublingual Immuno-therapy. Journal of Allergy and Clinical Immunology, 129, 1020-1030.
http://dx.doi.org/10.1016/j.jaci.2012.02.014

has been cited by the following article:

• TITLE: IL-10 Inhibits LPS-Induced Expression of miR-147 in Murine Macrophages

  AUTHORS: Leah N. Cardwell, Brian K. Weaver

  KEYWORDS: IL-10, Lipopolysaccharide, Macrophage, Inflammation, MicroRNA

  JOURNAL NAME: Advances in Biological Chemistry, Vol.4 No.4, June 26, 2014

  ABSTRACT: Interleukin-10 (IL-10) mediates an anti-inflammatory response that constrains immune responses and limits inflammation-associated pathology. IL-10 does so, in part, by selectively inhibiting pro-inflammatory cytokine and chemokine expression induced in macrophages in response to Toll-like receptor (TLR) signaling. The IL-10-mediated anti-inflammatory response is executed through the activation of STAT3 leading to induction of target genes referred to as IL-10-induced genes. As miRNAs have emerged as important negative regulators of gene expression in various systems, we sought to address whether the IL-10-mediated anti-inflammatory response acts through regulated expression of miRNA genes. Using quantitative PCR-based arrays, we examined 140 miRNA genes with putative roles in inflammation for changes in expression in response to IL-10 and lipopoly-saccharide (LPS) in primary mouse macrophages. IL-10 stimulation resulted in the inhibition of miR-147 expression induced in response to LPS, while having a potentiating effect on the induction of miR-455. miR-147 is the second TLR-induced miRNA, in addition to miR-155, identified to be counter-regulated by IL-10. Its suppression by IL-10 suggests that miR-147 may have an unknown pro-inflammatory function in TLR-triggered macrophages. The results extend the notion that IL-10 selectively regulates expression of miRNA genes, and that miRNA-mediated pathways are a component of the IL-10-mediated anti-inflammatory response.