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Kaya, G., Tran, C., Sorg, O., et al. (2006) Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism. PLoS Medicine, 3, 2291-2303.
http://dx.doi.org/10.1371/journal.pmed.0030493

has been cited by the following article:

  • TITLE: The Effects of a Hyaluronan Lotion with a Molecular Weight of around 50 - 110 kDa on the Aged Atrophic Skin

    AUTHORS: Asako Ito

    KEYWORDS: Hyaluronic Acid, Anti-Aging, PCNA, Filaggrin, 11βHSD1, 11βHSD2, Atrophic Skin

    JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.4 No.3, May 28, 2014

    ABSTRACT: Background: Hyaluronic acids act upon keratinocytes via CD44 receptors and regulate proliferation and differentiation. Some cosmetic hyaluronan lotions manufactured based upon the fact are nowadays available. Aims: To evaluate a cosmetic hyaluronan lotion (Dr. Fukaya’s skin repair lotion or Hyaluprotect) from the viewpoint of anti-aging effects and to consider its mechanism. Patients/Methods: In ten healthy volunteers at the age over 60, immunohistochemical research of the biopsied skin was performed before and after the application of the hyaluronan lotion for two weeks. Results: Expression of PCNA in the lower epidermis increased in 8 of 10 subjects. Filaggrin expression of the upper epidermis increased in 6 subjects. 11βHSD1 decreased in 5 subjects and 11βHSD2 increased in 5 subjects. Conclusions: The proliferative and differentiative effects of the hyaluronan lotion upon keratinocytes were confirmed immunohistologically. There is a possibility that hyaluronic acids work through the regulation of corticosteroids by 11βHSD1 and 11βHSD2.