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Hartmann, P., Stock, K.F. and Distl, O. (2012) Multivariate Prediction of Breeding Values for Canine Hip and Elbow Dysplasia as Well as Humeral Osteochondrosis in the Bermese Mountain Dog. Berl Munch Tierarztl Wochenschr, 125, 432-440.

has been cited by the following article:

  • TITLE: The Relation between Canine Hip Dysplasia, Genetic Diversity and Inbreeding by Breed

    AUTHORS: Frank H. Comhaire

    KEYWORDS: Genetic Diversity, Effective Population Size, Inbreeding, Hip Dysplasia

    JOURNAL NAME: Open Journal of Veterinary Medicine, Vol.4 No.5, May 13, 2014

    ABSTRACT: Objectives: To assess the relation between the prevalence of canine hip dysplasia, inbreeding and genetic diversity by breed. Methods: Retrospective pedigree analysis of 9 breeds based on a reference population of 41,728 individuals, and hip dysplasia assessment in 1745 dogs. Results: Hip dysplasia was less common among breeds with higher coefficient of inbreeding, lower genetic diversity, and highest contribution of one single ancestor to the population. Inbreeding not exceeding 3.25% should be considered safe since it will maintain a sufficiently high genetic diversity within the breed. Clinical Significance: Together with published data on single breeds, the present findings question the general assumption that line-breeding or in-breeding has an adverse effect on the prevalence of hip dysplasia. Hip assessment is indicated in all breeds, but better methods are needed for selecting dogs suitable for reproduction.