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Author(s): |
Zaili Luo, Shandong Provincial Key Laboratory Of Animal Cells and Developmental Biology,School of Life Science, Shandong University, Jinan, China 250100
Wenwen Wang, Shandong Provincial Key Laboratory Of Animal Cells and Developmental Biology,School of Life Science, Shandong University, Jinan, China 250100
Haibin Zhao, Shandong Provincial Key Laboratory Of Animal Cells and Developmental Biology,School of Life Science, Shandong University, Jinan, China 250100
Yongxiang Shi, Shandong Provincial Key Laboratory Of Animal Cells and Developmental Biology,School of Life Science, Shandong University, Jinan, China 250100 |
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Abstract: |
Grape seed proanthocyanidin is a class of polyphenolic compounds with strong anti-oxidation. To study the protection of grape seed proanthocyanidin on zebrafish’s early stage embryos from the damage of UVB irradiation, grape seed extract (GSE)(1 mg/ml) was injected into fertilized eggs before they were treated with UVB (36 mJ/cm2). We found that the survival rate was significantly higher and the rate of abnormalities was lower in the GSE-treated embryos than in the untreated group. After UVB irradiation, a variety of abnormal embryos occurrred, the total antioxidative capacity decreased, SOD and CAT activities changed. While in the GSE-treated embryos, the total antioxidative capacity, SOD and CAT activities changed greatly. Our study provided evidence for GSE’s further extensive application as an antioxidant.
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