President and Chief Scientist (September 2003 – present), Gordon Life Science Institute, San Diego, CA 92130, USA.
Chairman of Scientific Committee and Honorary President (September 2003 – 2006), Tianjin Institute of Bioinformatics & Drug Discovery, Tianjin, China.
Advisory Professor (2004-present), Institute of Image Processing & Pattern Recognition, Shanghai Jiaotong University, Shanghai 200030, China.
Advisory Professor (2004-present), Institute of Bioinformatics, Donghua University, Shanghai 200051, China.
Advisory Professor (2007-present), Department of Bioinformatics and Biostatistics, College of Life Sciences and Biotechnology, Shanghai Jiaotong University. Shanghai 200030, China
Advisory Professor (2004-present), Department of Biomedical Engineering, Shanghai Jiaotong University. Shanghai 200030, China.
Advisory Professor (2002-2003), Bio-X Life Science Research Center, Shanghai Jiao-Tong University, Shanghai, China.
Advisory Professor (2007-present), Northwestern Polytechnical University, Xi’an 710072, Shanxi, China.
Advisory Professor (2007-present), Guangxi University, Nanning, Guangxi, 530004, China.
Advisory Professor (2007-present), Bioinfo Lab, Jin-De-Zhen Institute, Jing-De-Zhen 333000, China.
Advisory Professor (2000-present), Institute of Life Science & Biotechnology, Tianjin University, Tianjin, China.
Senior Research Advisor (April 2003 – September 2003), Research & Development, Pfizer, Kalamazoo, MI 49007-4940, USA.
Senior Research Advisor (1999 – 2003), Structural & Computational Chemistry, Research & Development, Pharmacia, Kalamazoo, MI 49007-4940, USA.
Joint/Adjunct Professor (1998-2000), National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Research Advisor (1992 – 1999), Bioinformatics/Computer-Aided Drug Discovery, Research & Development, Pharmacia & Upjohn, Kalamazoo, MI 49007-4940, USA.
Senior Principle Scientist (1987 – 1992), Department of Computational Chemistry, Upjohn Laboratories, Kalamazoo, MI 49001, USA.
Professor (1985 – 1986), Department of Biophysics, University of Rochester, Rochester, New York, USA.
Senior Research Scientist (1984 – 1985), Baker Laboratory of Chemistry, Cornell University, USA.
Visiting Associate Professor (1981 – 1983), Department of Chemistry, Cornell University, USA.
Visiting Associate Professor (1979 – 1980), Chemical Center of Lund University, Sweden, and Max-Planck-Institute of Biophysical Chemistry, Germany.
Associate Professor (1978-1979), Shanghai Institute of Biochemistry, Chinese Academy of Sciences, China.
Junior Scientist (1976 – 1978), Shanghai Institute of Biochemistry, Chinese Academy of Sciences, China.
SERVICES TO SCIENTIFIC RESEARCH COMMUNITY
Editor-in-Chief (2009-present) Health, http://www.scirp.org/journal/health/.
Editor-in-Chief (2009-present), Natural Science, http://www.scirp.org/journal/NS/.
Editor-in-Chief (2008-present), The Open Bioinformatics Journal, http://www.bentham.org/open/tobioij/
Editor-in-Chief (2008-present), Journal of Biomedical Science and Engineering, http://www.srpublishing.org/journal/jbise/
Editorial Board (2005 – present), Journal of Theoretical Biology, http://ees.elsevier.com/jtb/
Editorial Board (2008 – present), Journal of Biophysics, http://www.hindawi.com/journals/jbp/
Editor for Western USA (2006 – present), Protein & Peptide Letters, http://www.bentham.org/ppl
Associate Editor (2004 - present), Medicinal Chemistry, http://www.bentham.org/mc/index.htm
Editorial Board (2007 – present), Current Proteomics, http://www.bentham.org/cp/index.htm
Editorial Board (2003 - present), Cancer Therapy, http://www.cancer-therapy.org/
Editorial Advisory Board (2007 – present), The Open Biochemistry Journal, http://www.bentham.org/open/tobiocj/
Editorial Advisory Board (June 2000 - present), Current Protein and Peptide Science, http://www.bentham.org/cpps/
Editorial Board (2008 – present), Journal of Biomedicine and Biotechnology, http://www.hindawi.com/journals/jbb/editors.html.
Editorial Board (2008 – present), Journal of Amino Acids, http://www.sage-hindawi.com/journals/jaa/editors.html
Editorial Board (2008 – present), Interdisciplinary Sciences, http://www.springer.com/life+sci/bioinformatics/journal/12539
Section Editor for Bioinformatics (2004 - 2007), Amino Acids, http://www.springer.com/springerwiennewyork/life+sciences/journal/726
Guest Editor (2004, Vol.16, No.11), Current Medicinal Chemistry, http://www.bentham.org/cmc/
Guest Editor (2005, Vol.6, No.5), Current Protein & Peptide Science, http://www.bentham.org/cpps/
Grant reviewer of NIH, USA (2005 – present)
Grant reviewer of National Science of Foundation, USA (1989 - present).
Grant reviewer of Israel Science Foundation, Israel Academy of Sciences and Humanities (1994).
Journal reviewer (1985-present): Journal of American Chemical Society, PNAS, Nature Protocol, Plant Physiology, Journal of Proteome Research, Proteomics, Journal of Molecular Biology, Biochemical Journal, Journal of Cellular Biochemistry, Protein Science, Proteins, Protein Engineering, European Journal of Biochemistry, Analytical Biochemistry, Journal of Medicinal Chemistry, Journal of Chemical Information & Computer Science, Journal of Protein Chemistry, Biopolymers, Biophysical Journal, Journal of Computational Chemistry, Macromolecules, Biophysical Chemistry, Journal of Mathematical Chemistry, Journal of Theoretical Biology, Journal of Peptide Research, Journal of Leukocyte Biology, Comparative Biochemistry & Physiology, Biotechnology and Bioengineering, Nucleic Acids Research, Bioinformatics, BMW Bioinformatics, Journal of Physical Chemistry, Peptides, BioTechniques, Cancer Letter, FASEB, FEBS Letters, Current Medicinal Chemistry, Medicinal Chemistry, Current Protein & Peptide Science, International Journal of Peptide & Protein Research, Applied Genomics and Proteomics, Cancer Letters, Progress in Neurobiology, Cell Biology & Toxicology, Pattern Recognition Letters, Biosystem, Expert Review of Molecular Diagnostics, Expert Opinion on Drug Discovery, Physica A, Chemical Biology & Drug Discovery, et al.
Co-President of the 1st IEEE International Conference on Bioinformatics and Biomedical Engineering, July 6 to 8, 2007, Wuhan, China
Co-President of the 10th International Congress on Amino Acids and Proteins (ICAAP), August 21 to 26, 2007, Kallithea, Chalkidiki, Greece
Co-President of the 2nd IEEE International Conference on Bioinformatics and Biomedical Engineering, May 16 to 18, 2008, Shanghai, China.
Co-Chair of the 3rd IEEE International Conference on Bioinformatics and Biomedical Engineering, June 11 to 13, 2009, Beijing, China.
Co-Chair of the 4th IEEE International Conference on Bioinformatics and Biomedical Engineering, June 11 to 13, 2010, Chengdu, China.
RESEARCH INTERESTS
(1) Prediction and modeling of drug-discovery-related proteins, such as GABA receptors, SARS coronavirus proteinase, apoptosis proteins, membrane ion-channels, G-protein-coupled receptors, adhesion proteins, growth hormones, tau protein kinases, GFAT (for diabetes), b-secretases (for Alzheimer disease), antifreeze proteins, dopamine receptors, as well as those targeted for finding drugs against various infectious diseases and CNS diseases.
(2) Development of various novel methods in bioinformatics and proteomics, such as predicting HIV protease cleavage sites, protein subcellular location, membrane protein type, signal peptide, protein quaternary attribute, enzyme family classes and sub-classes, enzyme active sites, protein tight turns, and protein structural classes.
(3) Introduction of physical conceptions to elucidate various marvelous dynamic mechanisms in biomacromolecules, such as allosteric transition, cooperativity effects, and intercalation between DNA and drugs.
(4) Development of graphical rules for studying enzyme kinetics and protein folding dynamics.
(5) Investigation of protein structural characters and revelation of their origin.
(6) Introduction of diagrammatic approach for codon usage analysis.
(7) Investigation of internal collective motion of biomacromolecules and its biological functions.
INVITED TALKS
Over 100 invited presentations at various International Scientific Meetings.