[1]
|
Hebb, D.O. (1947) The Effects of Early Experience on Problem-Solving at Maturity. American Psychologist, 2, 737-745.
|
[2]
|
Rosenzweig, M.R. and Bennett, E.L. (1996) Psychobiology of Plasticity: Effects of Training and Experience on Brain and Behavior. Behavioural Brain Research, 78, 57-65. https://doi.org/10.1016/0166-4328(95)00216-2
|
[3]
|
Rosenzweig, M.R., Bennett, E.L. and Diamond, M.C. (1972) Brain Changes in Response to Experience. Scientific American, 226, 22-29. https://doi.org/10.1038/scientificamerican0272-22
|
[4]
|
Nilsson, M., Perfilieva, E., Johansson, U., Orwar, O. and Eriksson, P.S. (1999) Enriched Environment Increases Neurogenesis in the Adult Rat Dentate Gyrus and Improves Spatial Memory. Journal of Neurobiology, 39, 569-578. https://doi.org/10.1002/(SICI)1097-4695(19990615)39:4<569::AI D-NEU10>3.0.CO;2-F
|
[5]
|
Stern, Y. (2002) What Is Cognitive Reserve? Theory and Research Application of the Reserve Concept. Journal of the International Neuropsychological Society, 8, 448. https://doi.org/10.1017/S1355617702813248
|
[6]
|
Van, P.H., Kempermann, G. and Gage, F.H. (2000) Neural Consequences of Environmental Enrichment. Nature Reviews Neuroscience, 1, 191-198. https://doi.org/10.1038/35044558
|
[7]
|
Blake, M. and Mitchell, G. (2016) Horticultural Therapy in Dementia Care: A Literature Review. Nursing Standard, 30, 41-47. https://doi.org/10.7748/ns.30.21.41.s44
|
[8]
|
Wu, H.-Y., et al. (2018) Effect of Horticultural Therapy on Cognitive Function and Quality of Life in Patients with Mild-to-Moderate Alzheimer Disease. Chinese Journal of Multiple Organ Diseases in the Elderly, 3, 197-201.
|
[9]
|
Will, B., et al. (2004) Recovery from Brain Injury in Animals: Relative Efficacy of Environmental Enrichment, Physical Exercise or Formal Training (1990-2002). Progress in Neurobiology, 72, 167-182. https://doi.org/10.1016/j.pneurobio.2004.03.001
|
[10]
|
Rosenzweig, M.R., et al. (1978) Social Grouping Cannot Account for Cerebral Effects of Enriched Environments. Brain Research, 153, 563-576. https://doi.org/10.1016/0006-8993(78)90340-2
|
[11]
|
Jankowsky, J.L., et al. (2005) Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer’s Disease. Journal of Neuroscience, 25, 5217-5224. https://doi.org/10.1523/JNEUROSCI.5080-04.2005
|
[12]
|
Baumans, V. (2005) Environmental Enrichment for Laboratory Rodents and Rabbits: Requirements of Rodents, Rabbits, and Research. Ilar Journal, 46, 162-170. https://doi.org/10.1093/ilar.46.2.162
|
[13]
|
Wang, Z.X., et al. (2003) The Effect of Music on Spatial Memory of Rat. Chinese Journal of Behavioral Medical Science, 12, 622-623.
|
[14]
|
Hu, J.J., Wang, Z., et al. (2007) Preliminary Studies of Spacial Learning and Memory and Its Mechanism of Mice in Different Music Circumstance. Journal of Jinan University (Medicine Edition), 28, 132-135.
|
[15]
|
Liu, Y.Y., et al. (2004) Effects of Different Light-Dark Cycle on Learning and Memory in Mice. Space Medicine & Medical Engineering, 17, 381-382.
|
[16]
|
Cao, L., et al. (2008) The Effect of Odors on Learning, Memory and Intracerebral Acetylcholinesterase Activity of the Mice. Chinese Journal of Gerontology, 28, 1465-1467.
|
[17]
|
Nithianantharajah, J. and Hannan, A.J. (2006) Enriched Environments, Experience-Dependent Plasticity and Disorders of the Nervous System. Nature Reviews Neuroscience, 7, 697-709. https://doi.org/10.1038/nrn1970
|
[18]
|
Singh, P., Heera, P.K. and Kaur, G. (2003) Expression of Neuronal Plasticity Markers in Hypoglycemia Induced Brain Injury. Molecular & Cellular Biochemistry, 247, 69-74. https://doi.org/10.1023/A:1024105120087
|
[19]
|
Schrijver, N.C., Pallier, P.N., Brown, V.J. and Würbel, H. (2004) Double Dissociation of Social and Environmental Stimulation on Spatial Learning and Reversal Learning in Rats. Behavioural Brain Research, 152, 307-314. https://doi.org/10.1016/j.bbr.2003.10.016
|
[20]
|
van Praag, H., Kempermann, G. and Gage, F.H. (1999) Running Increases Cell Proliferation and Neurogenesis in the Adult Mouse Dentate Gyrus. Nature Neuroscience, 2, 266-270. https://doi.org/10.1038/6368
|
[21]
|
Leal-Galicia, P., Castañeda-Bueno, M., Quiroz-Baez, R. and Arias, C. (2008) Long-Term Exposure to Environmental Enrichment Since Youth Prevents Recognition Memory Decline and Increases Synaptic Plasticity Markers in Aging. Neurobiology of Learning & Memory, 90, 511-518. https://doi.org/10.1016/j.nlm.2008.07.005
|
[22]
|
Arne, H., et al. (2009) Environmental Enrichment Enhances Cellular Plasticity in Transgenic Mice with Alzheimer-Like Pathology. Experimental Neurology, 216, 184-192. https://doi.org/10.1016/j.expneurol.2008.11.027
|
[23]
|
Arnaiz, S.L., et al. (2004) Enriched Environment, Nitric Oxide Production and Synaptic Plasticity Prevent the Aging-Dependent Impairment of Spatial Cognition. Molecular Aspects of Medicine, 25, 91-101. https://doi.org/10.1016/j.mam.2004.02.011
|
[24]
|
Altman, J. and Das, G.D. (1964) Autoradiographic Examination of the Effects of Enriched Environment on the Rate of Glial Multiplication in the Adult Rat Brain. Nature, 204, 1161-1163. https://doi.org/10.1038/2041161a0
|
[25]
|
Epp, J.R., Spritzer, M.D. and Galea, L.A. (2007) Hippocampus-Dependent Learning Promotes Survival of New Neurons in the Dentate Gyrus at a Specific Time during Cell Maturation. Neuroscience, 149, 273-285. https://doi.org/10.1016/j.neuroscience.2007.07.046
|
[26]
|
Wolf, S.A., et al. (2006) Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer’s Disease. Biological Psychiatry, 60, 1314-1323. https://doi.org/10.1016/j.biopsych.2006.04.004
|
[27]
|
Kempermann, G., Kuhn, H.G. and Gage, F.H. (1997) More Hippocampal Neurons in Adult Mice Living in an Enriched Environment. Nature, 386, 493-495. https://doi.org/10.1038/386493a0
|
[28]
|
Kempermann, G., Gast, D. and Gage, F.H. (2002) Neuroplasticity in Old Age: Sustained Fivefold Induction of Hippocampal Neurogenesis by Long-Term Environmental Enrichment. Annals of Neurology, 52, 135-143. https://doi.org/10.1002/ana.10262
|
[29]
|
Segovia, G., Yagüe, A.G., García-Verdugo, J.M. and Mora, F. (2006) Environmental Enrichment Promotes Neurogenesis and Changes the Extracellular Concentrations of Glutamate and GABA in the Hippocampus of Aged Rats. Brain Research Bulletin, 70, 8-14. https://doi.org/10.1016/j.brainresbull.2005.11.005
|
[30]
|
Pham, T.M., et al. (1999) Changes in Brain Nerve Growth Factor Levels and Nerve Growth Factor Receptors in Rats Exposed to Environmental Enrichment for One Year. Neuroscience, 94, 279-286. https://doi.org/10.1016/S0306-4522(99)00316-4
|
[31]
|
Young, D., Lawlor, P.A., Leone, P., Dragunow, M. and During, M.J. (1999) Environmental Enrichment Inhibits Spontaneous Apoptosis, Prevents Seizures and Is Neuroprotective. Nature Medicine, 5, 448-453. https://doi.org/10.1038/7449
|
[32]
|
Cao, L., et al. (2004) VEGF Links Hippocampal Activity with Neurogenesis, Learning and Memory. Nature Genetics, 36, 827-835. https://doi.org/10.1038/ng1395
|
[33]
|
Pham, T.M., et al. (2002) Environmental Influences on Brain Neurotrophins in Rats. Pharmacology Biochemistry & Behavior, 73, 167-175. https://doi.org/10.1016/S0091-3057(02)00783-9
|
[34]
|
Klein, S.L., Lambert, K.G., Durr, D., Schaefer, T. and Waring, R.E. (1994) Influence of Environmental Enrichment and Sex on Predator Stress Response in Rats. Physiology & Behavior, 56, 291-297. https://doi.org/10.1016/0031-9384(94)90197-X
|
[35]
|
Benaroya Milshtein, N., et al. (2015) Environmental Enrichment in Mice Decreases Anxiety, Attenuates Stress Responses and Enhances Natural Killer Cell Activity. European Journal of Neuroscience, 20, 1341-1347. https://doi.org/10.1111/j.1460-9568.2004.03587.x
|
[36]
|
Williams, B.M., et al. (2001) Environmental Enrichment: Effects on Spatial Memory and Hippocampal CREB Immunoreactivity. Physiology & Behavior, 73, 649-658. https://doi.org/10.1016/S0031-9384(01)00543-1
|
[37]
|
Zhong, L., et al. (2007) Preweaning Exposure to Enriched Environment Induces Hippocampal Neurogenesis: Experiment with Rats. National Medical Journal of China, 87, 1559.
|
[38]
|
Zhong, L., et al. (2009) Calmodulin Activation Is Required for the Enhancement of Hippocampal Neurogenesis Following Environmental Enrichment. Neurological Research, 31, 707-713. https://doi.org/10.1179/174313209X380856
|
[39]
|
Bröcher, S., Artola, A. and Singer, W. (1992) Agonists of Cholinergic and Noradrenergic Receptors Facilitate Synergistically the Induction of Long-Term Potentiation in Slices of Rat Visual Cortex. Brain Research, 573, 27-36. https://doi.org/10.1016/0006-8993(92)90110-U
|
[40]
|
Blennow, K., de Leon, M.J. and Zetterberg, H. (2006) Alzheimer’s Disease. The Lancet, 368, 387-403. https://doi.org/10.1016/S0140-6736(06)69113-7
|
[41]
|
Patterson, C. (2018) World Alzheimer Report 2018. The State of the Art of Dementia Research: New Frontiers. An Analysis of Prevalence, Incidence, Cost and Trends. Alzheimer’s Disease International.
|
[42]
|
Yong, J.I., et al. (2014) A 200-Year History of Alzheimer’s Disease. Chinese Journal of Contemporary Neurology & Neurosurgery, 14, 156-160.
|
[43]
|
Ge, R. (2014) Progress in the Researches of Alzeimer’s Disease. Chinese and Foreign Medical Research, 9, 155-157.
|
[44]
|
De Felice, F.G. (2013) Alzheimer’s Disease and Insulin Resistance: Translating Basic Science into Clinical Applications. Journal of Clinical Investigation, 123, 531-539. https://doi.org/10.1172/JCI64595
|
[45]
|
Selkoe, D.J. (2001) Alzheimer’s Disease: Genes, Proteins, and Therapy. Physiological Reviews, 81, 741-766. https://doi.org/10.1152/physrev.2001.81.2.741
|
[46]
|
Torreilles, F. and Touchon, J. (2002) Pathogenic Theories and Intrathecal Analysis of the Sporadic form of Alzheimer’s Disease. Progress in Neurobiology, 66, 191-203. https://doi.org/10.1016/S0301-0082(01)00030-2
|
[47]
|
Lee, H.G., et al. (2004) Challenging the Amyloid Cascade Hypothesis: Senile Plaques and Amyloid-Beta as Protective Adaptations to Alzheimer Disease. Annals of the New York Academy of Sciences, 1019, 1-4. https://doi.org/10.1196/annals.1297.001
|
[48]
|
Zhang, W., et al. (2012) Multiple Inflammatory Pathways Are Involved in the Development and Progression of Cognitive Deficits in APPswe/PS1dE9 Mice. Neurobiology of Aging, 33, 2661-2677. https://doi.org/10.1016/j.neurobiolaging.2011.12.023
|
[49]
|
Sondag, C.M. and Combs, C.K. (2010) Amyloid Precursor Protein Cross-Linking Stimulates Beta Amyloid Production and Pro-Inflammatory Cytokine Release in Monocytic Lineage Cells. Journal of Neurochemistry, 97, 449-461. https://doi.org/10.1111/j.1471-4159.2006.03759.x
|
[50]
|
Streit, W.J. (2010) Microglia and Alzheimer’s Disease Pathogenesis. Journal of Neuroscience Research, 77, 1-8. https://doi.org/10.1002/jnr.20093
|
[51]
|
Tweedie, D., et al. (2012) Tumor Necrosis Factor-α Synthesis Inhibitor 3,6’-Dithiothalidomide Attenuates Markers of Inflammation, Alzheimer Pathology and Behavioral Deficits in Animal Models of Neuroinflammation and Alzheimer’s Disease. Journal of Neuroinflammation, 9, 106. https://doi.org/10.1186/1742-2094-9-106
|
[52]
|
Eikelenboom, P., et al. (2012) Whether, When and How Chronic Inflammation Increases the Risk of Developing Late-Onset Alzheimer’s Disease. Alzheimer’s Research & Therapy, 4, 15. https://doi.org/10.1186/alzrt118
|
[53]
|
Wallin, Å.K., Blennow, K., Andreasen, N. and Minthon, L. (2006) CSF Biomarkers for Alzheimer’s Disease: Levels of β-Amyloid, Tau, Phosphorylated Tau Relate to Clinical Symptoms and Survival. Dementia & Geriatric Cognitive Disorders, 21, 131-138. https://doi.org/10.1159/000090631
|
[54]
|
Tapiola, T., et al. (1997) The Level of Cerebrospinal Fluid Tau Correlates with Neurofibrillary Tangles in Alzheimer’s Disease. NeuroReport, 8, 3961-3963. https://doi.org/10.1097/00001756-199712220-00022
|
[55]
|
Verdier, Y., Zarándi, M. and Penke, D.B. (2004) Amyloid β-Peptide Interactions with Neuronal and Glial Cell Plasma Membrane: Binding Sites and Implications for Alzheimer’s Disease. Journal of Peptide Science, 10, 229-248. https://doi.org/10.1002/psc.573
|
[56]
|
Ittner, L.M. and Götz, J. (2010) Amyloid-β and Tau—A Toxic Pas de Deux in Alzheimer’s Disease. Nature Reviews Neuroscience, 12, 65-72.
|
[57]
|
Amadoro, G., et al. (2011) Endogenous Aβ Causes Cell Death via Early Tau Hyperphosphorylation. Neurobiology of Aging, 32, 969-990. https://doi.org/10.1016/j.neurobiolaging.2009.06.005
|
[58]
|
Zhang, S.J., et al. (2012) Amyloid-β and Tau in Alzheimer’s Disease. Chemistry of Life, 32, 254-258.
|
[59]
|
Smith, M.A., Zhu, X., et al. (2010) Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment. Journal of Alzheimer’s Disease, 19, 363-372. https://doi.org/10.3233/JAD-2010-1239
|
[60]
|
Perry, G., et al. (2000) Oxidative Damage in Alzheimer’s Disease: The Metabolic Dimension. International Journal of Developmental Neuroscience, 18, 417-421. https://doi.org/10.1016/S0736-5748(00)00006-X
|
[61]
|
Liu, F., et al. (2015) The Oxidative Stress and Antioxidative Therapy in Alzheimer’s Disease. Journal of Jinan University (Natural Science & Medicine Edition), 36, 406-409.
|
[62]
|
Li, L., Zhang, X. and Le, W. (2010) Autophagy Dysfunction in Alzheimer’s Disease. Neurodegenerative Diseases, 7, 265-271. https://doi.org/10.1159/000276710
|
[63]
|
Yoon, S.Y. and Kim, D.H. (2016) Alzheimer’s Disease Genes and Autophagy. Brain Research, 1649, 201-209. https://doi.org/10.1016/j.brainres.2016.03.018
|
[64]
|
Sanchez-Varo, R., et al. (2012) Abnormal Accumulation of Autophagic Vesicles Correlates with Axonal and Synaptic Pathology in Young Alzheimer’s Mice Hippocampus. Acta Neuropathologica, 123, 53-70. https://doi.org/10.1007/s00401-011-0896-x
|
[65]
|
Kim, S., et al. (2014) NDP52 Associates with Phosphorylated Tau in Brains of an Alzheimer Disease Mouse Model. Biochemical & Biophysical Research Communications, 454, 196-201. https://doi.org/10.1016/j.bbrc.2014.10.066
|
[66]
|
Schaeffer, V.R. and Goedert, M. (2012) Stimulation of Autophagy Is Neuroprotective in a Mouse Model of Human Tauopathy. Autophagy, 135, 2169-2177.
|
[67]
|
Hamano, T., et al. (2010) Autophagic-Lysosomal Perturbation Enhances Tau Aggregation in Transfectants with Induced Wild-Type Tau Expression. European Journal of Neuroscience, 27, 1119-1130. https://doi.org/10.1111/j.1460-9568.2008.06084.x
|
[68]
|
Peters, O. (2012) Alzheimer’s Disease: Are Non-Steroidal Anti-Inflammatory Drugs Effective? Deutsche Medizinische Wochenschrift, 137, 2627.
|
[69]
|
Menting, K.W. and Claassen, J.A. (2014) β-Secretase Inhibitor: A Promising Novel Therapeutic Drug in Alzheimer’s Disease. Frontiers in Aging Neuroscience, 6, 165. https://doi.org/10.3389/fnagi.2014.00165
|
[70]
|
Bozzali, M., et al. (2013) Brain Tissue Modifications Induced by Cholinergic Therapy in Alzheimer’s Disease. Human Brain Mapping, 34, 3158-3167. https://doi.org/10.1002/hbm.22130
|
[71]
|
Men, Y., et al. (2015) Advances in Active Constituents of Traditional Chinese Medicines for Treating Alzheimer’s Disease. Letters in Biotechnology, 4, 587-590.
|
[72]
|
Wang, Q. (2012) Advances in the Researches of Acetylcholinesterase Inhibitors in the Treatment of Alzheimer’s Disease. Science & Technology Information, 24, 127.
|
[73]
|
Sevigny, J., et al. (2016) The Antibody Aducanumab Reduces Aβ Plaques in Alzheimer’s Disease. Nature, 537, 50-56. https://doi.org/10.1038/nature19323
|
[74]
|
Congdon, E.E. and Sigurdsson, E.M. (2018) Tau-Targeting Therapies for Alzheimer Disease. Nature Reviews. Neurology, 14, 399-415. https://doi.org/10.1038/s41582-018-0013-z
|
[75]
|
Doody, R.S., et al. (2014) Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer’s Disease. The New England Journal of Medicine, 370, 311-321. https://doi.org/10.1056/NEJMoa1312889
|
[76]
|
Bohrmann, B., et al. (2012) Gantenerumab: A Novel Human Anti-Aβ Antibody Demonstrates Sustained Cerebral Amyloid-β Binding and Elicits Cell-Mediated Removal of Human Amyloid-β. Journal of Alzheimer’s Disease, 28, 49-69. https://doi.org/10.3233/JAD-2011-110977
|
[77]
|
Salloway, S., et al. (2014) Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer’s Disease. The New England Journal of Medicine, 370, 322-333. https://doi.org/10.1056/NEJMoa1304839
|
[78]
|
Colacurcio, D.J., Pensalfini, A., Jiang, Y. and Nixon, R.A. (2017) Dysfunction of Autophagy and Endosomal-Lysosomal Pathways: Roles in Pathogenesis of Down Syndrome and Alzheimer’s Disease. Free Radical Biology & Medicine, 114, 40-51. https://doi.org/10.1016/j.freeradbiomed.2017.10.001
|
[79]
|
Li, Q., Liu, Y. and Sun, M. (2017) Autophagy and Alzheimer’s Disease. Cellular & Molecular Neurobiology, 37, 377-388. https://doi.org/10.1007/s10571-016-0386-8
|
[80]
|
Gu, J., Congdon, E.E. and Sigurdsson, E.M. (2013) Two Novel Tau Antibodies Targeting the 396/404 Region Are Primarily Taken Up by Neurons and Reduce Tau Protein Pathology. Journal of Biological Chemistry, 288, 33081-33095. https://doi.org/10.1074/jbc.M113.494922
|
[81]
|
Lei, W.H., et al. (2011) The Current Status and Prospect of Healing Garden. Chinese Landscape Architecture, 27, 31-36.
|
[82]
|
Koike, H., et al. (1999) Membrane-Anchored Metalloprotease MDC9 Has an Alpha-Secretase Activity Responsible for Processing the Amyloid Precursor Protein. Biochemical Journal, 343, 371-375. https://doi.org/10.1042/bj3430371
|
[83]
|
Wang, L., et al. (2014) Effects of Aluminium on β-Amyloid (1-42) and Secretases (APP-Cleaving Enzymes) in Rat Brain. Neurochemical Research, 39, 1338-1345. https://doi.org/10.1007/s11064-014-1317-z
|
[84]
|
Liu, H.L., Zhao, G., Zhang, H. and Shi, L.-D. (2013) Long-Term Treadmill Exercise Inhibits the Progression of Alzheimer’s Disease-Like Neuropathology in the Hippocampus of APP/PS1 Transgenic Mice. Behavioural Brain Research, 256, 261-272. https://doi.org/10.1016/j.bbr.2013.08.008
|
[85]
|
Nichol, K.E., et al. (2008) Exercise Alters the Immune Profile in Tg2576 Alzheimer Mice toward a Response Coincident with Improved Cognitive Performance and Decreased Amyloid. Journal of Neuroinflammation, 5, 13. https://doi.org/10.1186/1742-2094-5-13
|
[86]
|
Garcíamesa, Y., et al. (2012) Melatonin plus Physical Exercise Are Highly Neuroprotective in the 3xTg-AD Mouse. Neurobiology of Aging, 33, 1124.e13-1124.e29.
|
[87]
|
Adlard, P.A., Perreau, V.M., Pop, V. and Cotman, C.W. (2005) Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer’s Disease. Journal of Neuroscience, 25, 4217-4221. https://doi.org/10.1523/JNEUROSCI.0496-05.2005
|
[88]
|
Yu, F., et al. (2014) Effects of Treadmill Exercise on β-Amyloid Precursor Protein and Tau Protein Gene Expressions in Hippocampus of D-Galactose Alzheimer’s Disease Rats. Chinese Journal of Rehabilitation Medicine, 29, 1010-1015.
|
[89]
|
Yu, F., et al. (2016) Research on Effect of α-Secretase on Regulating Hippocampal APP and Aβ-42 in APP/PS1 Transgenic Mice of Alzeimer’s Disease after Voluntary Wheel Running. China Sport Science, 36, 49-55.
|
[90]
|
Kong, F.J., et al. (2013) Effect of Regular Aerobic Exercises on Learning and Memory of APP/PS1 Mice. Journal of Neuroscience and Mental Health, 13, 232-234.
|
[91]
|
Marco, M., et al. (2014) Environmental Enrichment Strengthens Corticocortical Interactions and Reduces Amyloid-β Oligomers in Aged Mice. Frontiers in Aging Neuroscience, 6, 1.
|
[92]
|
Maesako, M., et al. (2012) Environmental Enrichment Ameliorated High-Fat Diet-Induced Aβ Deposition and Memory Deficit in APP Transgenic Mice. Neurobiology of Aging, 33, 1011.e11-1011.e23. https://doi.org/10.1016/j.neurobiolaging.2011.10.028
|
[93]
|
Li, J.Z., et al. (2015) Effects of Enriched Environment on Neurons Apoptosis in Hippocampal CA1 Region in Senescence Accelerated Mouse. Chinese Journal of Behavioral Medicine and Brain Science, 24, 113-116.
|
[94]
|
Lazarov, O., et al. (2005) Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice. Cell, 120, 701-713. https://doi.org/10.1016/j.cell.2005.01.015
|
[95]
|
Hu, Y.S., et al. (2010) Complex Environment Experience Rescues Impaired Neurogenesis, Enhances Synaptic Plasticity, and Attenuates Neuropathology in Familial Alzheimer’s Disease-Linked APPswe/PS1ΔE9 Mice. The FASEB Journal, 24, 1667-1681. https://doi.org/10.1096/fj.09-136945
|
[96]
|
Lahianicohen, I., et al. (2011) Moderate Environmental Enrichment Mitigates Tauopathy in a Neurofibrillary Tangle Mouse Model. Journal of Neuropathology and Experimental Neurology, 70, 610-621. https://doi.org/10.1097/NEN.0b013e318221bfab
|
[97]
|
Leem, Y.H., et al. (2010) Repression of Tau Hyperphosphorylation by Chronic Endurance Exercise in Aged Transgenic Mouse Model of Tauopathies. Journal of Neuroscience Research, 87, 2561-2570. https://doi.org/10.1002/jnr.22075
|
[98]
|
Kaytor, M.D. and Orr, H.T. (2002) The GSK3β Signaling Cascade and Neurodegenerative Disease. Current Opinion in Neurobiology, 12, 275-278. https://doi.org/10.1016/S0959-4388(02)00320-3
|
[99]
|
Fan, D., Li, J., Zheng, B., Hua, L. and Zuo, Z. (2016) Enriched Environment Attenuates Surgery-Induced Impairment of Learning, Memory, and Neurogenesis Possibly by Preserving BDNF Expression. Journal of Molecular Neurobiology, 53, 344-354. https://doi.org/10.1007/s12035-014-9013-1
|
[100]
|
Ziegler-Waldkirch, S., Marksteiner, K., Stoll, J., et al. (2018) Environmental Enrichment Reverses Aβ Pathology during Pregnancy in a Mouse Model of Alzheimer’s Disease. Acta Neuropathologica Communications, 6, 44. https://doi.org/10.1186/s40478-018-0549-6
|
[101]
|
Xu, H., et al. (2016) Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers. Journal of Neuroscience, 36, 9041-9056. https://doi.org/10.1523/JNEUROSCI.1023-16.2016
|
[102]
|
Ambrée, O., et al. (2006) Reduction of Amyloid Angiopathy and Aβ Plaque Burden after Enriched Housing in TgCRND8 Mice: Involvement of Multiple Pathways. American Journal of Pathology, 169, 544-552. https://doi.org/10.2353/ajpath.2006.051107
|
[103]
|
Zhou, C.J., et al. (2017) Effect of Enriched Environment on Cognitive Function in Patients with Early and Middle-Aged Dementia. Psychological Doctor, 23, 8.
|
[104]
|
Ying, X. (2017) Effect of Comprehensive Rehabilitation Training on Cognitive Function and Quality of Life in Patients with Alzheimer’s Disease. Chinese Journal of Rural Medicine and Pharmacy, 24, 76-77.
|
[105]
|
Zhang, J., et al. (2015) Effect of Comprehensive Rehabilitation Training on Cognitive Function and Daily Living Ability of Patients with Alzheimer’s Disease. Shanxi Medical Journal, 44, 785-787.
|
[106]
|
Van Dellen, A., Blakemore, C., Deacon, R., York, D. and Hannan, A.J. (2000) Delaying the Onset of Huntington’s in Mice. Nature, 404, 721-722. https://doi.org/10.1038/35008142
|
[107]
|
Lazic, S.E., et al. (2010) Neurogenesis in the R6/1 Transgenic Mouse Model of Huntington’s Disease: Effects of Environmental Enrichment. European Journal of Neuroscience, 23, 1829-1838. https://doi.org/10.1111/j.1460-9568.2006.04715.x
|
[108]
|
Frick, K.M. and Fernandez, S.M. (2003) Enrichment Enhances Spatial Memory and Increases Synaptophysin Levels in Aged Female Mice. Neurobiology of Aging, 24, 615-626. https://doi.org/10.1016/S0197-4580(02)00138-0
|
[109]
|
Gelfo, F., Cutuli, D., Foti, F., et al. (2011) Enriched Environment Improves Motor Function and Increases Neurotrophins in Hemicerebellar Lesioned Rats. Neurorehabil Neural Repair, 25, 243-252. https://doi.org/10.1177/1545968310380926
|
[110]
|
Prusky, G.T., Reidel, C. and Douglas, R.M. (2000) Environmental Enrichment from Birth Enhances Visual Acuity but Not Place Learning in Mice. Behavioural Brain Research, 114, 11-15. https://doi.org/10.1016/S0166-4328(00)00186-8
|
[111]
|
Nithianantharajah, J., Levis, H. and Murphy, M. (2004) Environmental Enrichment Results in Cortical and Subcortical Changes in Levels of Synaptophysin and PSD-95 Proteins. Neurobiology of Learning & Memory, 81, 200-210. https://doi.org/10.1016/j.nlm.2004.02.002
|
[112]
|
Chen, J. (2008) Noninvasive Study on Brain Neurotransmitter in the Patients with Alzheimer’s Disease. Guangzhou Medical Journal, 39, 7-9.
|
[113]
|
Pu, Z.X., et al. (2007) Influence of Environmental Enrichment at Different Stages of Development on the Expression of p38 in Hippocampus of Hypoxia-Ischemic Brain Damaged Rats. Chinese Journal of Child Health Care, 15, 632-634.
|
[114]
|
Dezsi, G., et al. (2016) Environmental Enrichment Imparts Disease-Modifying and Transgenerational Effects on Genetically-Determined Epilepsy and Anxiety. Neurobiology of Disease, 93, 129-136. https://doi.org/10.1016/j.nbd.2016.05.005
|
[115]
|
Crews, L., et al. (2008) Alpha-Synuclein Alters Notch-1 Expression and Neurogenesis in Mouse Embryonic Stem Cells and in the Hippocampus of Transgenic Mice. Journal of Neuroscience, 28, 4250-4260. https://doi.org/10.1523/JNEUROSCI.0066-08.2008
|
[116]
|
Steiner, B., et al. (2006) Enriched Environment Induces Cellular Plasticity in the Adult Substantia Nigra and Improves Motor Behavior Function in the 6-OHDA Rat Model of Parkinson’s Disease. Experimental Neurology, 199, 291-300. https://doi.org/10.1016/j.expneurol.2005.11.004
|
[117]
|
Xie, H.Y., et al. (2011) New Progress in the Application of Enriched Environment in Neurodegenerative Diseases. Chinese Journal of Rehabilitation Medicine, 26, 592-596.
|