Buffer standards for the physiological pH of the zwitterionic buffer 3-[N-tris(hydroxymethyl)methylamino]-2-hydroxypropanesulfonic Acid (TAPSO) From (278.15 to 328.15) K

Lakshmi N. Roy, Rabindra N. Roy, Blake M. Bodendorfer, Zachary M. Downs, Stephen D. Rocchio, Jessica M. Stegner, Isaac B. Henson

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DOI: 10.4236/jbpc.2011.24048                

Abstract

The second dissociation constant, pK₂, and related thermodynamic quantities for TAPSO have been previously determined and reported from the temperatures (278.15 to 328.15) K. In the current study there are five buffer solutions without NaCl and five buffer solutions with NaCl present which yield an ionic strength (I = 0.16 mol·kg^-1) similar to that of blood plasma. These buffer solutions have been evaluated in the temperature range of (278.15 to 328.15) K using the extended Debye-Hückel equation, due to the limitations of the Bates-Guggenheim convention such that it is only valid when I < 0.1 mol·kg^-1. The liquid junction potential (E_j) values between the TAPSO solution and the saturated KCl calomel electrode solution have been estimated at (298.15 and 310.15) K using a flowing junction cell measurement. The previously mentioned E_j values have been used in determining the operational pH values at (298.15 and 310.15) K. These TAPSO buffer solutions are recommended as reference solutions for pH measurements in saline media with an ionic strength of I = 0.16 mol·kg^-1.

Keywords

Zwitterionic; Buffer; pH; Liquid Junction; Physiological

Conflicts of Interest

The authors declare no conflicts of interest.

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