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Assessment of Human Skeletal Muscle Contraction and Force by Diffusion Tensor Imaging

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DOI: 10.4236/ojrad.2015.54026    3,484 Downloads   3,990 Views   Citations

ABSTRACT

We aimed to investigate the association between mobility and skeletal muscle strength by using magnetic resonance diffusion tensor imaging (DTI). This study included 20 healthy male volunteers (mean age, 21.8 ± 1.1 years). The maximum voluntary strength (MVC) of each participant was measured with the ankle joint in plantar and dorsal flexion using an instrument for measuring muscle strength. Moreover, magnetic resonance imaging (MRI) was performed with the ankle joint at rest, in plantar flexion, and in dorsal flexion. For imaging, a 1.5-T MRI device was used, and a diffusion-weighted stimulated echo-planar imaging pulse sequence. Tensor eigenvalues (λ), fractional anisotropy (FA), and the apparent diffusion coefficient (ADC) were calculated from data obtained by DTI. The resulting MRI data were compared to the data on muscle mobility or strength and statistically analyzed. Regarding changes in DTI indices during muscle movements, anisotropy of the tibialis anterior was significantly increased from rest to plantar flexion (P < 0.01), whereas no significant change was observed in dorsal flexion (n.s.). In contrast, the extent of significant changes in anisotropy of the medial gastrocnemius (mGC) and soleus (SOL) was small at plantar flexion (mGC, P < 0.01; SOL, n.s.), whereas the indices were significantly increased at dorsal flexion (P < 0.01). Regarding the correlation between MVC of each skeletal muscle and the DTI indices, FA and λ3 were significantly correlated in movements involving the muscles, whereas no significant correlation was observed in movements not involving them. Changes in intramuscular water molecules by elongation and contraction of the skeletal muscle fibers could be assumed to affect changes in diffusional anisotropy. When muscles contract, the space between myocytes was reduced and they might become increasingly dense. Moreover, diffusional anisotropy increased with increasing MVC, whereas ADC remained unchanged. DTI was suggested to produce measurements similar to the degree of muscle strength.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Hata, J. , Nagata, H. , Endo, K. , Komaki, Y. , Sato, M. , Numano, T. and Yagi, K. (2015) Assessment of Human Skeletal Muscle Contraction and Force by Diffusion Tensor Imaging. Open Journal of Radiology, 5, 189-198. doi: 10.4236/ojrad.2015.54026.

References

[1] Le Bihan, D., Mangin, J.F., Poupon, C., et al. (2001) Diffusion Tensor Imaging: Concepts and Applications. Journal of Magnetic Resonance Imaging, 13, 534-546.
http://dx.doi.org/10.1002/jmri.1076
[2] Mukherjee, P., Bahn, M.M., Mckinstry, R.C., Shimony, J.S., Cull, T.S., Akbudak, E., et al. (2000) Differences between Gray Matter and White Matter Water Diffusion in Stroke: Diffusion-Tensor MR Imaging in 12 Patients. Radiology, 215, 211-220.
http://dx.doi.org/10.1148/radiology.215.1.r00ap29211
[3] Bozzali, M., Cercignani, M., Sormani, M.P., Comi, G. and, Filippi, M. (2002) Quantification of Brain Gray Matter Damage in Different MS Phenotypes by Use of Diffusion Tensor MR Imaging. American Journal of Neuroradiology, 23, 985-988.
[4] Pfefferbaum, A., Sullivan, E.V., Hedehus, M., Lim, K.O., Adalsteinsson, E. and Moseley, M. (2000) Age-Related Decline in Brain White Matter Anisotropy Measured with Spatially Corrected Echo-Planar Diffusion Tensor Imaging. Magnetic Resonance in Medicine, 44, 259-268.
http://dx.doi.org/10.1002/1522-2594(200008)44:2<259::AID-MRM13>3.0.CO;2-6
[5] Aagaard, P., Andersen, J.L., Dyhre-Poulsen, P., Leffers, A.M., Wagner, A., Magnusson, S.P., et al. (2001) A Mechanism for Increased Contractile Strength of Human Pennate Muscle in Response to Strength Training: Changes in Muscle Architecture. Journal of Physiology, 534, 613-623.
[6] Scott, S.H., Engstrom, C.M. and Loeb, G.E. (1993) Morphometry of Human Thigh Muscles. Determination of Fascicle Architecture by Magnetic Resonance Imaging. Journal of Anatomy, 182, 249-257.
[7] Bruhn, H., Frahm, J., Gyngell, M.L., Merboldt, K.D., Hanicke, W. and Sauter, R. (1991) Localized Proton NMR Spectroscopy Using Stimulated Echoes: Applications to Human Skeletal Muscle in Vivo. Magnetic Resonance in Medicine, 17, 82-94.
http://dx.doi.org/10.1002/mrm.1910170113
[8] Mancini, D.M., Walter, G., Reichek, N., et al. (1992) Contribution of Skeletal Muscle Atrophy to Exercise Intolerance and Altered Muscle Metabolism in Heart Failure. Circulation, 85, 1364-1373.
http://dx.doi.org/10.1161/01.CIR.85.4.1364
[9] Kemp, G.J., Taylor, D.J. and Radda, G.K. (1993) Control of Phosphocreatine Resynthesis during Recovery from Exercise in Human Skeletal Muscle. NMR in Biomedicine, 6, 66-72.
http://dx.doi.org/10.1002/nbm.1940060111
[10] Takahashi, H., Kuno, S., Miyamoto, T., Yoshioka, H., Inaki, M., Akima, H., et al. (1994) Changes in Magnetic Resonance Images in Human Skeletal Muscle after Eccentric Exercise. European Journal of Applied Physiology and Occupational Physiology, 69, 408-413.
http://dx.doi.org/10.1007/bf00865404
[11] Ploutz-Snyder, L.L., Nyren, S., Cooper, T.G., Potchen, E.J. and Meyer, R.A. (1997) Different Effects of Exercise and Edema on T2 Relaxation in Skeletal Muscle. Magnetic Resonance in Medicine, 37, 676-682.
http://dx.doi.org/10.1002/mrm.1910370509
[12] Ploutz-Snyder, L.L., Tesch, P.A., Crittenden, D.J. and Dudley, G.A. (1995) Effect of Unweighting on Skeletal Muscle Use during Exercise. Journal of Applied Physiology, 79, 168-175.
[13] Foley, J.M., Jayaraman, R.C., Prior, B.M., Pivarnik, J.M. and Meyer, R.A. (1999) MR Measurements of Muscle Damage and Adaptation after Eccentric Exercise. Journal of Applied Physiology, 87, 2311-2318.
[14] Heemskerk, A.M., Strijkers, G.J., Vilanova, A., Drost, M.R. and Nicolay, K. (2005) Determination of Mouse Skeletal Muscle Architecture using Three-Dimensional Diffusion Tensor Imaging. Magnetic Resonance in Medicine, 53, 1333-1340.
http://dx.doi.org/10.1002/mrm.20476
[15] Budzik, J.F., Le Thuc, V., Demondion, X., Morel, M., Chechin, D. and Cotton, A. (2007) In Vivo MR Tractography of Thigh Muscles Using Diffusion Imaging: Initial Results. European Radiology, 17, 3079-3085.
http://dx.doi.org/10.1007/s00330-007-0713-z
[16] Kan, J.H., Heemskerk, A.M., Ding, Z., Gregory, A., Mencio, G., Spindler, K. and Damon, B.M. (2009) DTI-Based Muscle Fiber Tracking of the Quadriceps Mechanism in Lateral Patellar Dislocation. Journal of Magnetic Resonance Imaging, 29, 663-670.
http://dx.doi.org/10.1002/jmri.21687
[17] Sinha, S., Sinha, U. and Edgerton, V.R. (2006) In Vivo Diffusion Tensor Imaging of the Human Calf Muscle. Journal of Magnetic Resonance Imaging, 24, 182-190.
http://dx.doi.org/10.1002/jmri.20593
[18] McMillan, A.B., Shi, D., Pratt, S.J. and Lovering, R.M. (2011) Diffusion Tensor MRI to Assess Damage in Healthy and Dystrophic Skeletal Muscle after Lengthening Contractions. Journal of Biomedicine and Biotechnology, 2011, Article ID: 970726.
http://dx.doi.org/10.1155/2011/970726
[19] Wickiewicz, T.L., Roy, R.R., Powell, P.L., Perrine, J.J. and Edgerton, V.R. (1984) Muscle Architecture and Force-Velocity Relationships in Humans. Journal of Applied Physiology, 57, 435-443.
[20] Lehnert, A., Machann, J., Helms, G., Claussen, C.D. and Schick, F. (2004) Diffusion Characteristics of Large Molecules Assessed by Proton MRS on a Whole-Body MR System. Magnetic Resonance Imaging, 22, 39-46.
http://dx.doi.org/10.1016/j.mri.2003.05.007
[21] Hata, J., Yagi, K., Hikishima, K, Numano, T., Goto, M. and Yano, K. (2013) Characteristics of Diffusion-Weighted Stimulated Echo Pulse Sequence in Human Skeletal Muscle. Radiological Physics and Technology, 6, 92-97.
http://dx.doi.org/10.1007/s12194-012-0174-1
[22] Basser, P. and Pierpaoli, C. (1996) Microstructural and Physiological Features of Tissues Elucidated by Quantitative-Diffusion-Tensor MRI. Journal of Magnetic Resonance, 111, 209-219.
http://dx.doi.org/10.1006/jmrb.1996.0086
[23] Suzuki, Y., Yagi, K., Kodama, T. and Shinoura, N. (2009) Corticospinal Tract Extraction Combining Difusion Tensor Tractography with fMRI in Patients with Brain Diseases. Magnetic Resonance in Medicine, 8, 9-16.
http://dx.doi.org/10.2463/mrms.8.9
[24] Gordon, A.M., Huxley, A.F. and Julian, F.J. (1966) The Variation in Isometric Tension with Sarcomere Length in Vertebrate Muscle Fibres. Journal of Physiology, 184, 170-192.
http://dx.doi.org/10.1113/jphysiol.1966.sp007909
[25] Fukunaga, T., Roy, R.R., Shellock, F.G., Hodgson, J.A., Day, M.K., Lee, P.L., Kwong-Fu, H. and Edgerton, V.R. (1992) Physiological Cross-Sectional Area of Human Leg Muscles Based on Magnetic Resonance Imaging. Journal of Orthopaedic Research, 10, 928-934.
http://dx.doi.org/10.1002/jor.1100100623
[26] Fukunaga, T., Ichinose, Y., Ito, M., Kawakami, Y., Fukashiro, S., et al. (1997) Determination of Fascicle Length and Pennation in a Contracting Human Muscle in Vivo. Journal of Applied Physiology, 82, 354-358.
[27] Lustig, M., Donoho, D. and Pauly, J.M. (2007) Sparse MRI: The Application of Compressed Sensing for Rapid MR Imaging. Magnetic Resonance in Medicine, 58, 1182-1195.
http://dx.doi.org/10.1002/mrm.21391

  
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