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Nano-Coupling of Cephalosporin Antibiotics with Fe3O4 Nanoparticles: Trojan Horse Approach in Antimicrobial Chemotherapy of Infections Caused by Klebsiella spp.

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DOI: 10.4236/jbnb.2015.63021    4,617 Downloads   5,320 Views   Citations

ABSTRACT

In the present study we had an aim to develop the methods of functionalizing the surface of magnetite nanoparticles with cefotaxime and ceftriaxone antibiotics. The quantitative analysis of the nanostructured cephalosporins was determined by Atom Absorbance Spectroscopy (AAS) and based on the Lambert-Beer law. The engineered nanostructures were tested on gram-negative microorganisms Klebsiella spp., of Enterobacteriaceae, and gram-positive bacteria Staphylococcus aureus, each having multi-drug resistance properties.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Hasanova, U. , Ramazanov, M. , Maharramov, A. , Eyvazova, Q. , Agamaliyev, Z. , Parfyonova, Y. , Hajiyeva, S. , Hajiyeva, F. and Veliyeva, S. (2015) Nano-Coupling of Cephalosporin Antibiotics with Fe3O4 Nanoparticles: Trojan Horse Approach in Antimicrobial Chemotherapy of Infections Caused by Klebsiella spp.. Journal of Biomaterials and Nanobiotechnology, 6, 225-235. doi: 10.4236/jbnb.2015.63021.

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