Tumor Resistance to Molecularly Targeted Agents
James Chen, Peter S. Edelstein, Philip J. Johnson, Robert Lustig, Lucien Ooi
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DOI: 10.4236/jct.2011.22033   PDF    HTML     5,469 Downloads   10,116 Views   Citations

Abstract

Despite the development of new targeted cancer therapies, primary and secondary tumors continue to be a leading cause of suffering and mortality worldwide. The complexity and heterogeneity of malignancies ultimately result in tumor resistance to therapies, such as EGFR inhibitiors, anti-angiogenesis agents, and tyrosine kinase inhibitors. An example of targeted therapies for renal cell carcinoma is presented, including the SAE profile and efficacy of 6 targeted agents. Although survival is improved, resistance and an increased side effect profile diminish the benefits of these agents. New agents are needed which are pathway independent and which can overcome tumor resistance without adding to the side effect profile of current therapies.

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J. Chen, P. Edelstein, P. Johnson, R. Lustig and L. Ooi, "Tumor Resistance to Molecularly Targeted Agents," Journal of Cancer Therapy, Vol. 2 No. 2, 2011, pp. 258-265. doi: 10.4236/jct.2011.22033.

Conflicts of Interest

The authors declare no conflicts of interest.

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