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Sonodynamic Antitumor Effect of Benzoporphyrin Derivative Monoacid Ring A on KLN205 Cells

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DOI: 10.4236/jct.2011.22011    4,189 Downloads   7,833 Views   Citations

ABSTRACT

Sonodynamic therapy is a new cancer treatment based on the synergetic effect of ultrasound and a drug. In this study, ultrasonically induced antitumor effects of benzoporphyrin derivative monoacid ring A (BPD-MA) on KLN205 cells were investigated. KLN205 cells were irradiated at an ultrasonic frequency of 3 MHz with 10 μg/ml BPD-MA. The ultrasonically induced cell damage significantly increased as an ultrasonic intensity and ultrasound exposure time increased. Confocal microscopic examination revealed that the irradiated cells were induced chromatin condensation and phosphatidylserine exposure. The synergistic effect of the ultrasound exposure and BPD-MA on the tumor cell adhesion rate was significant.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

T. Osaki, M. Tajima, Y. Okamoto, S. Takagi, T. Tsuka, T. Imagawa and S. Minami, "Sonodynamic Antitumor Effect of Benzoporphyrin Derivative Monoacid Ring A on KLN205 Cells," Journal of Cancer Therapy, Vol. 2 No. 2, 2011, pp. 99-104. doi: 10.4236/jct.2011.22011.

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