Thrombotic Microangiopathy Induced by Hyperthermal Intraperitoneal Chemotherapy with Mitomycin C

Mahir Köksal, Robert J van Ginkel, Jan G Zijlstra

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DOI: 10.4236/ss.2011.24037                

Abstract

A patient with pseudomyxoma peritonei underwent Hyperthermal Intraperitoneal Chemotherapy (HIPEC) with Mitomycin C after which she developed thrombotic microangiopathy. This syndrome mimicked possi-ble surgical complications. Treatment with plasma exchange resolved the syndrome and the patient recov-ered completely. This is the first description of thrombotic microangiopathy early after a single dose intrap-eritoneal Mitomycin C.

Keywords

HIPEC, Toxicity, HUS-TTP

Conflicts of Interest

The authors declare no conflicts of interest.

References

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