Share This Article:

Effects of Buspirone on Anxiolytic Effects of Magnesium in Male Mice

Abstract Full-Text HTML Download Download as PDF (Size:278KB) PP. 657-662
DOI: 10.4236/pp.2014.57075    3,287 Downloads   4,371 Views   Citations

ABSTRACT

Anxiolytic-like activity of magnesium chloride has been exhibited in the elevated plus-maze test in mice, in several studies. Buspirone is an anxiolytic psychoactive drug of the azapirone chemical class that is not related to benzodiazepines, unlike most drugs predominately used. The purpose of the present study was to examine interaction between magnesium (Mg) and buspirone as a partial agonist of 5-HT1A receptors in producing anxiolytic-like activity in the elevated plus maze. The anxiolytic-like effect of Mg (50, 100 and 200 mg/kg, orally), buspirone (5 mg/kg, i.p) and its interaction with Mg (50 mg/kg) was evaluated after ten days treatment. Mg given at all doses (50, 100 and 200 mg/kg) and buspirone (5 mg/kg) induced an anxiolytic-like effect significantly increasing the percentage of the time spent in the open arms (%OAT), the percentage of the open arm entries (%OAE) and number of total entries. Percent time spend in open arms was reduced when buspirone coadministered with Mg (50 mg/kg) compared to Mg alone. However, the number of entries did not change significantly. No synergistic interaction (increased time in open arms and number of open arm entries) between Mg and buspirone was observed, in this test, on the contrary, %OAT preserved about buspirone effects and %OAE remained around Mg effect. The obtained data indicate that Mg may act partly via serotonergic receptors due to buspirone’s inhibitory action as a partial agonist of serotonin receptor.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Jahromy, M. , Golbaghi, G. , Mohajer, A. , Poor, F. and Riazi, M. (2014) Effects of Buspirone on Anxiolytic Effects of Magnesium in Male Mice. Pharmacology & Pharmacy, 5, 657-662. doi: 10.4236/pp.2014.57075.

References

[1] (2013) Diagnostic and Statistical Manual of Mental Disorders American Psychiatric Association, 5th Edition, American Psychiatric Publishing, Arlington, 189-195.
[2] Patel, G. and Fancher, T.L. (2013) In the Clinic. Generalized Anxiety Disorder. Annals of Internal Medicine, 159, 1-11.
http://dx.doi.org/10.7326/0003-4819-159-11-201312030-01006
[3] Lydiard, R.B. (2003) The Role of GABA in Anxiety Disorders. Journal of Clinical Psychiatry, 64, 21-27.
[4] Dunlop, B.W. and Davis, P.G. (2008) Combination Treatment with Benzodiazepines and SSRIs for Comorbid Anxiety and Depression: A Review. Prim Care Companion. Journal of Clinical Psychiatry, 10, 222-228.
http://dx.doi.org/10.4088/PCC.v10n0307
[5] Fulton, B. and Brogden, R.N. (1997) Buspirone. CNS Drugs, 7, 68-88.
http://dx.doi.org/10.2165/00023210-199707010-00007
[6] Buspirone Monograph. Drugs.com.
[7] Jadhav, S.A., Gaikwad, R.V., Gaonkar, R.K., Thorat, V.M., Gursale, S.C. and Balsara, J.J. (2008) Dose-Dependent Response of Central Dopaminergic Systems to Buspirone in Mice. Indian Journal of Experimental Biology, 46, 704-714.
[8] Cohn, J.B., Rickels, K. and Steege, J.F. (1989) A Pooled, Double-Blind Comparison of the Effects of Buspirone, Diazepam and Placebo in Women with Chronic Anxiety. Current Medical Research and Opinion, 11, 304-320.
http://dx.doi.org/10.1185/03007998909115213
[9] Murphy, S.M., Owen, R. and Tyrer, P. (1989) Comparative Assessment of Efficacy and Withdrawal Symptoms after 6 and 12 Weeks’ Treatment with Diazepam or Buspirone. The British Journal of Psychiatry: The Journal of Mental Science, 154, 529-534.
[10] Ryan, M.F. (1991) The Role of Magnesium in Clinical Biochemistry: An Overview. Annals of Clinical Biochemistry, 28, 19-26. http://dx.doi.org/10.1177/000456329102800103
[11] Cardoso, C.C., Lobato, K.R., Binfaré, R.W., Ferreira, P.K., Rosa, A.O., Santos, A.R.S. and Rodrigues, A.L.S. (2009) Evidence for the Involvement of the Monoaminergic System in the Antidepressant-Like Effect of Magnesium. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33, 235-242.
http://dx.doi.org/10.1016/j.pnpbp.2008.11.007
[12] Poleszak, E., Szewczyk, B., Kêdzierska, E., Wlaz, P., Pilc, A. and Nowak, G. (2004) Antidepressant- and Anxiolytic-Like Activity of Magnesium in Mice. Pharmacology Biochemistry and Behavior, 78, 7-12.
http://dx.doi.org/10.1016/j.pbb.2004.01.006
[13] Poleszak, E., Wlaz, P., Kêdzierska, E., Nieoczym, D., Wyska, E., Szymura-Oleksiak, J., Fidecka, S., et al. (2006) Immobility Stress Induces Depression-Like Behavior in the Forced Swim Test in Mice: Effect of Magnesium and Imipramine. Pharmacological Research, 58, 746-752.
[14] Hiremath, Sh.B., Anand, S., Srinivas, L.D. and Rashed, M.R. (2010) Effect of Calcium on Anxiolytic Activity of Diazepam and Verapamil in Rats. Indian Journal of Pharmacology, 42, 406-408.
http://dx.doi.org/10.4103/0253-7613.71889
[15] Joshi, M., Akhtar, M., Najmi, A.K., Khuroo, A.H. and Goswami, D. (2012) Effect of Zinc in Animal Models of Anxiety, Depression and Psychosis. Human & Experimental Toxicology, 31, 1237-1243.
http://dx.doi.org/10.1177/0960327112444938
[16] Poleszak, E., Wlaz, P., Kêdzierska, E., Nieoczym, D., Wróbel, A., Fidecka, S. and Pilc, A. (2007) Nowak G: NMDA/ Glutamate Mechanism of Antidepressant-Like Action of Magnesium in Forced Swim Test in Mice. Pharmacology Biochemistry and Behavior, 88, 158-164.
http://dx.doi.org/10.1016/j.pbb.2007.07.018
[17] Poleszak, E., Wlaz, P., Wróbel, A., Dybala, M., Sowa, M., Fidecka, S., Pilc, A. and Nowak, G. (2007) Activation of the NMDA/Glutamate Receptor Complex Antagonizes the NMDA Antagonist-Induced Antidepressant-Like Effects in the Forced Swim Test. Pharmacological Research, 59, 595-600.
[18] Lister, R.G. (1987) The Use of a Plus-Maze to Measure Anxiety in the Mouse. Psychopharmacology, 92, 180-185.
http://dx.doi.org/10.1007/BF00177912
[19] Dunn, R.W., Corbett, R. and Fielding, S. (1989) Effects of 5-HTlA Receptor Agonist and NMDA Receptor Antagonist in the Social Interaction Test and the Elevated plus Maze. European Journal of Pharmacology, 169, 1-10.
http://dx.doi.org/10.1016/0014-2999(89)90811-X
[20] Poleszak, E. (2008) Benzodiazepine/GABAA Receptors Are Involved in Magnesium-Induced Anxiolytic-Like Behavior in Mice. Pharmacological Reports, 60, 483-489.

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.