Resolution of Alcohol Racemate by Oil

Adi Wolfson, Nadia Komyagina, Christina Dlugy, Janine Blumenfeld

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DOI: 10.4236/gsc.2011.11002                

Abstract

Vegetable oil was successfully used as solvent and acyl donor in the kinetic resolution of several secondary alcohol racemates yielding high enantioselectivities. Using vegetable oil as solvent and acyl donor allowed easy separation of the pure alcohol enantiomer by extraction with methanol, by distillation under reduced pressure, or by column chromatography.

Keywords

Oil, Kinetic Resolution, Lipase, Separation

Conflicts of Interest

The authors declare no conflicts of interest.

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