An iterative Approach to Deriving Drug Infusions

David P. Crankshaw

Department of Pharmacology, The University of Melbourne, Melbourne, Victoria, Australia.

DOI: 10.4236/eng.2012.410B039                

Abstract

A simple iterative process can be used to generate intravenous drug infusion profiles. It overcomes limitations in deriving compartmental pharmacokinetic models and has application to evaluation of new drugs and to clinical practice.

Keywords

Pharmacokinetics; Drug Delivery; Intravenous Infusion

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	P. S. A. Glass, S. L. Shafer and J. G. Reeves, “Intravenous drug delivery systems,” In Miller’s Anesthesia, vol. 1, R. G. Miller Ed. Churchill Livingstone Elsevier, 2010, pp. 826-830.
[2]	J. A. H. Davidson, A. D. Macleod, J. C. Howie, M. White, G. N. C. Kenny, “Effective concentration 50 for propofol with and without 67% nitrous oxide,” Acta. Anaesthesiol. Scand. Vol. 37, pp. 458-464, 1993.
[3]	B. Marsh, M. White, N. Morton and G. N. C. Kenny, “Pharmacokinetic model driven infusion of propofol in children,” Anesth. Analg. Br. J. Anaesth. vol. 67, pp. 41-48, 1991.
[4]	Stanpump (Steven L. Shafer: Stanford University Anesthesiology Service, 112A PAVAMC, 3801 Miranda Ave, Palo Alto, CA 94304, USA).?
[5]	S. L. Beal, L. B. Scheiner, “NONMEM User’s Guide,” San Francisco, University of California San Francisco, 1979.
[6]	D. P. Crankshaw, M. J. Brown and A. R. Bjorksten, “A comparison of parametric and non-parametric approaches to target-controlled infusion of propofol,” Anaesth. Intensive Care vol. 38, pp. 437-444, May 2010.
[7]	D. P. Crankshaw, M. D. Boyd, A. R. Bjorksten, “Plasma Drug Efflux - A new approach to optimization of drug infusion for constant blood concentration of thiopental and methohexital,” Anesthesiology, vol. 67 pp. 32-41, 1987.
[8]	D. P. Crankshaw, D. J. Morgan, G. H. Beemer and F. Karasawa, “Preprogrammed infusion of alfentanil to constant arterial plasma concentration,” Anesth. Analg. vol, 76, pp. 556-561, 1993.
[9]	D. P. Crankshaw, F. Karasawa, “A method for imple-menting programmed infusion of thiopentone and methohexitone with a simple infusion pump,” Anaesth. Intensive Care, vol. 17, pp 496-499, 1989.
[10]	D. P. Crankshaw, “Intravenous delivery systems: Australian Perspective,” In Intravenous Anaesthesia. Ed. P. F White, Williams & Wilkins, Philadelphia. 1997, pp 539-544.