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Variable β-globin haplotypes in Saudi β thalassemia population

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DOI: 10.4236/ojgen.2013.33019    2,769 Downloads   4,802 Views   Citations

ABSTRACT

Twenty two haplotypes were generated from a pool of 60 unrelated Saudi β thalassemia major patients using previously described restriction sites in the β globin gene. Linkage disequilibrium analysis of the polymorphic sites was also conducted, a few identified haplotypes were novel while the remainder was previously reported, haplotype1222212 was the most frequent haplotype in the study group and a strong linkage disequilibrium between two polymorphic restriction sites in these β thalassemia patients was uncovered.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Shinwari, J. , Alshehri, T. , Tahir, A. , Jefri, A. , AlMomen, A. , Bakheet, D. , AlAnazi, M. , Warsy, A. and Tassan, N. (2013) Variable β-globin haplotypes in Saudi β thalassemia population. Open Journal of Genetics, 3, 171-173. doi: 10.4236/ojgen.2013.33019.

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