Photoisomerization of Provitamin D in Hydrogel Matrix

I. P. Terenetskaya, Yu. M. Samchenko, T. N. Orlova, N. A. Pasmurceva, P. S. Kapinos, I. E. Boldeskul, Z. R. Ulberg

Institute of Physics, NAS Ukraine, Prospekt Nauki, Kyiv, Ukraine.
Ovcharenko Institute of Biocolloid Chemistry, NAS Ukraine, Acad. Vernadsky Blvd., Kyiv, Ukraine.

DOI: 10.4236/soft.2013.22003                

Abstract

Study of interfacial processes between incorporated biomolecules and hydrogel matrix is of primary importance for the application of synthetic hydrogels as biomaterials, sensors, etc. Their hydrophilic nature, however, hampers fat-soluble biomolecule incorporation. We synthesized N-isopropylacrylamide (NIPAAm)- and Acrylamide (AA)-based hydrogels with hydrophilic-lipophilic balance that under specific conditions permit homogeneous incorporation of provitamins D₃(7-dehydrocholesterol) and D₂(ergosterol) dissolved in ethanol. Similarity of provitamins D photoisomerization in such hydrogel matrices with the photoreaction in ethanol shows great potential of the novel material for personal dosimetry of biologically active ‘antirachitic’ UV radiation.

 

Keywords

Hydrogels; Provitamin D Photoisomerization; UV Biodosimeter

Conflicts of Interest

The authors declare no conflicts of interest.

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